Antispermatogenic effects of artemether: An animal model

Various antimalarial drugs have been shown to exert different adverse effects; however, scanty information is available for artemether-induced potential side effects. The present study assessed effects of artemether on lipid profile, sperm count, and histological features of testes in an animal mode...

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Bibliographic Details
Published in:Toxicological and environmental chemistry 2009-04, Vol.91 (3), p.511-519
Main Authors: Adekunle, A.S., Agbedana, E.O., Oyewopo, O., Adedeji, A.L., Adebisi, J.A.
Format: Article
Language:English
Subjects:
antimalaria
artemether
lipid
lipoproteins
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Summary:Various antimalarial drugs have been shown to exert different adverse effects; however, scanty information is available for artemether-induced potential side effects. The present study assessed effects of artemether on lipid profile, sperm count, and histological features of testes in an animal model. The mean total cholesterol, high-density lipoproteins, low-density lipoproteins, triglyceride, and total proteins in mice-administered artemether were higher compared with controls. The mean sperm counts in mice treated with artemether were reduced when compared with controls. In addition, it was observed that artemether affected the histopathology of seminiferous epithelia and Leydig cells. Evidence indicates that artemether exerts adverse effects in mice testes.
ISSN:0277-2248
1029-0486
DOI:10.1080/02772240802188072