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Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Monotes engleri

The synthesis of (±)-monotesone-A, an antifungal component of Monotes engleri, as well as its four structural analogues were accomplished starting from the corresponding MOM-protected phloracetophenone and benzaldehyde derivatives. Antifungal activities of the five flavanone derivatives were studied...

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Bibliographic Details
Published in:Natural product research 2008-03, Vol.22 (5), p.383-392
Main Authors: Kenéz, Ágnes, Lestár, Zsombor, Lenkey, Béla, Antus, Sándor
Format: Article
Language:English
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Summary:The synthesis of (±)-monotesone-A, an antifungal component of Monotes engleri, as well as its four structural analogues were accomplished starting from the corresponding MOM-protected phloracetophenone and benzaldehyde derivatives. Antifungal activities of the five flavanone derivatives were studied against Candida albicans (14053 and ATCC 10231), Candida inconspicua, Candida dubliniensis and Candida krusei. ¶ Dedicated to Professor György Hajós on the occasion of his 60th birthday.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410701339055