Carbazole alkaloids isolated from the branch and leaf extracts of Clausena lansium

The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1–9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2018-07, Vol.16 (7), p.509-512
Main Authors: PENG, Wen-Wen, ZHENG, Li-Xia, JI, Chang-Jiu, SHI, Xu-Gen, XIONG, Zhong-Hua, SHANGGUAN, Xin-Chen
Format: Article
Language:English
Subjects:
Carbazole alkaloids
Clausena lansium
Cytotoxic activity
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Summary:The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1–9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines. Our results showed that compounds 2–6 exhibited varying degrees of cytotoxicity to cancer cells, with IC50 values ranging from 8.67 to 98.89 μmol·L−1.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(18)30087-6