Periodontitis may modulate long-non coding RNA expression

•It was determined for first-time expression profiles of different lncRNAs in different stages of periodontal disease.•The lncRNAs AC0001207, MZF1AS1, FGD5AS1 have not been reported to be associated with any disease in Vivo.•After the use of the Benjamini-Hochberg test, OIP5-AS1 lncRNA conserved rem...

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Published in:Archives of oral biology 2018-11, Vol.95, p.95-99
Main Authors: Sánchez-Muñoz, Fausto, Martínez-Coronilla, Gustavo, Leija-Montoya, Ana Gabriela, Rieke-Campoy, Ulises, Angelina Lopez-Carrasco, Rosa, de Lourdes Montaño-Pérez, María, Beltrán-Partida, Ernesto, Bojórquez-Anaya, Yolanda, Serafin-Higuera, Nicolas, González-Ramírez, Javier
Format: Article
Language:English
Subjects:
Adolescent
Adult
Case-Control Studies
Dentistry
Female
Humans
Long non-coding RNA
Male
Middle Aged
miRNA
Non-coding RNAs
OIP5-AS1
Periodontitis
Periodontitis - metabolism
Pilot Projects
Reverse Transcriptase Polymerase Chain Reaction
RNA, Long Noncoding - metabolism
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Summary:•It was determined for first-time expression profiles of different lncRNAs in different stages of periodontal disease.•The lncRNAs AC0001207, MZF1AS1, FGD5AS1 have not been reported to be associated with any disease in Vivo.•After the use of the Benjamini-Hochberg test, OIP5-AS1 lncRNA conserved remarkable changes. Periodontitis is a chronic inflammatory disease that compromises the integrity of the periodontium. Despite extensive research involving periodontitis, the detailed mechanisms underlying periodontal inflammation remain unclear. However, new important expression regulators have been emerging, such as non-coding RNAs, which are important determinants in the molecular control of the inflammatory process. Taking into consideration the vital role of non-coding RNAs, we determined for the first time the expression profiles of different long non-coding RNAs (lncRNAs) that are implicated in inflammation. In this study, we take periodontal samples of healthy subjects, patients with gingivitis and with periodontitis. In both disease groups, the lncRNA OIP5-AS1 expression levels were lower than levels in healthy subjects (P < 0.05). This study reveals new insights into the relative levels of OIP5-AS1 lncRNA in healthy, gingivitis and periodontal tissue, which may have important applications as a potential biomarker with protagonist activity in the development and manifestation of destructive periodontitis.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2018.07.023