Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study

Malignant ovarian germ cell tumors usually occur in young women. Until the 1970s, before establishment of systemic chemotherapy, malignant ovarian germ cell tumors had a very poor prognosis. Recently, prognosis has improved, and fertility-sparing treatment is being adopted in patients who desire to...

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Published in:American journal of obstetrics and gynecology 2018-10, Vol.219 (4), p.385.e1-385.e7
Main Authors: Tamauchi, Satoshi, Kajiyama, Hiroaki, Yoshihara, Masato, Ikeda, Yoshiki, Yoshikawa, Nobuhisa, Nishino, Kimihiro, Utsumi, Fumi, Niimi, Kaoru, Suzuki, Shiro, Kikkawa, Fumitaka
Format: Article
Language:English
Subjects:
bleomycin/etoposide/cisplatin therapy
cancer survivor
fertility-sparing treatment
malignant ovarian germ cell tumor
reproductive outcome
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Summary:Malignant ovarian germ cell tumors usually occur in young women. Until the 1970s, before establishment of systemic chemotherapy, malignant ovarian germ cell tumors had a very poor prognosis. Recently, prognosis has improved, and fertility-sparing treatment is being adopted in patients who desire to become pregnant. However, the number of malignant ovarian germ cell tumor survivors who actually became pregnant remains unknown. The present study aimed to clarify the reproductive outcomes in malignant ovarian germ cell tumor survivors by using data from a multicenter database and an additional survey on reproductive outcomes. The study used the Tokai Ovarian Tumor Study Group database on ovarian cancer patients. We assessed the database from 1986 through 2016 and selected malignant ovarian germ cell tumor patients
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2018.07.021