A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen

[Display omitted] •Natural polysaccharides are biocompatible, biodegradable, renewable and biologically active.•Cellulose, starch and glycogen are engineered to enrich drug release properties.•It is explored for anticancer drugs delivery, probiotic and cells.•Structural modification increases the bi...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2018-11, Vol.107, p.96-108
Main Authors: Gopinath, V., Saravanan, S., Al-Maleki, A.R., Ramesh, M., Vadivelu, Jamuna
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Bio-medical applications
Cellulose
Cellulose - pharmacology
Drug Delivery Systems
Glycogen
Glycogen - pharmacology
Natural polysaccharides
Polysaccharides - pharmacology
Starch
Starch - pharmacology
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Summary:[Display omitted] •Natural polysaccharides are biocompatible, biodegradable, renewable and biologically active.•Cellulose, starch and glycogen are engineered to enrich drug release properties.•It is explored for anticancer drugs delivery, probiotic and cells.•Structural modification increases the bioactivity to several folds. Natural polysaccharides are renewable with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment. Comprehensive investigations of polysaccharides are essential for our fundamental understanding of exploiting its potential as bio-composite, nano-conjugate and in pharmaceutical sectors. Polysaccharides are considered to be superior to other polymers, for its ease in tailoring, bio-compatibility, bio-activity, homogeneity and bio-adhesive properties. The main focus of this review is to spotlight the new advancements and challenges concerned with surface modification, binding domains, biological interaction with the conjugate including stability, polydispersity, and biodegradability. In this review, we have limited our survey to three essential polysaccharides including cellulose, starch, and glycogen that are sourced from plants, microbes, and animals respectively are reviewed. We also present the polysaccharides which have been extensively modified with the various types of conjugates for combating last-ditch pharmaceutical challenges.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2018.07.136