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A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen
[Display omitted] •Natural polysaccharides are biocompatible, biodegradable, renewable and biologically active.•Cellulose, starch and glycogen are engineered to enrich drug release properties.•It is explored for anticancer drugs delivery, probiotic and cells.•Structural modification increases the bi...
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| Published in: | Biomedicine & pharmacotherapy 2018-11, Vol.107, p.96-108 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c362t-f6b0f8bdd20af1b9b57542578e2b4f3626c9f694acf808aefc3a11a4120e00723 |
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| cites | cdi_FETCH-LOGICAL-c362t-f6b0f8bdd20af1b9b57542578e2b4f3626c9f694acf808aefc3a11a4120e00723 |
| container_end_page | 108 |
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| container_title | Biomedicine & pharmacotherapy |
| container_volume | 107 |
| creator | Gopinath, V. Saravanan, S. Al-Maleki, A.R. Ramesh, M. Vadivelu, Jamuna |
| description | [Display omitted]
•Natural polysaccharides are biocompatible, biodegradable, renewable and biologically active.•Cellulose, starch and glycogen are engineered to enrich drug release properties.•It is explored for anticancer drugs delivery, probiotic and cells.•Structural modification increases the bioactivity to several folds.
Natural polysaccharides are renewable with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment. Comprehensive investigations of polysaccharides are essential for our fundamental understanding of exploiting its potential as bio-composite, nano-conjugate and in pharmaceutical sectors. Polysaccharides are considered to be superior to other polymers, for its ease in tailoring, bio-compatibility, bio-activity, homogeneity and bio-adhesive properties. The main focus of this review is to spotlight the new advancements and challenges concerned with surface modification, binding domains, biological interaction with the conjugate including stability, polydispersity, and biodegradability. In this review, we have limited our survey to three essential polysaccharides including cellulose, starch, and glycogen that are sourced from plants, microbes, and animals respectively are reviewed. We also present the polysaccharides which have been extensively modified with the various types of conjugates for combating last-ditch pharmaceutical challenges. |
| doi_str_mv | 10.1016/j.biopha.2018.07.136 |
| format | article |
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•Natural polysaccharides are biocompatible, biodegradable, renewable and biologically active.•Cellulose, starch and glycogen are engineered to enrich drug release properties.•It is explored for anticancer drugs delivery, probiotic and cells.•Structural modification increases the bioactivity to several folds.
Natural polysaccharides are renewable with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment. Comprehensive investigations of polysaccharides are essential for our fundamental understanding of exploiting its potential as bio-composite, nano-conjugate and in pharmaceutical sectors. Polysaccharides are considered to be superior to other polymers, for its ease in tailoring, bio-compatibility, bio-activity, homogeneity and bio-adhesive properties. The main focus of this review is to spotlight the new advancements and challenges concerned with surface modification, binding domains, biological interaction with the conjugate including stability, polydispersity, and biodegradability. In this review, we have limited our survey to three essential polysaccharides including cellulose, starch, and glycogen that are sourced from plants, microbes, and animals respectively are reviewed. We also present the polysaccharides which have been extensively modified with the various types of conjugates for combating last-ditch pharmaceutical challenges.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2018.07.136</identifier><identifier>PMID: 30086465</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Bio-medical applications ; Cellulose ; Cellulose - pharmacology ; Drug Delivery Systems ; Glycogen ; Glycogen - pharmacology ; Natural polysaccharides ; Polysaccharides - pharmacology ; Starch ; Starch - pharmacology</subject><ispartof>Biomedicine & pharmacotherapy, 2018-11, Vol.107, p.96-108</ispartof><rights>2018 Elsevier Masson SAS</rights><rights>Copyright © 2018 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-f6b0f8bdd20af1b9b57542578e2b4f3626c9f694acf808aefc3a11a4120e00723</citedby><cites>FETCH-LOGICAL-c362t-f6b0f8bdd20af1b9b57542578e2b4f3626c9f694acf808aefc3a11a4120e00723</cites><orcidid>0000-0002-7917-8586</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30086465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gopinath, V.</creatorcontrib><creatorcontrib>Saravanan, S.</creatorcontrib><creatorcontrib>Al-Maleki, A.R.</creatorcontrib><creatorcontrib>Ramesh, M.</creatorcontrib><creatorcontrib>Vadivelu, Jamuna</creatorcontrib><title>A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>[Display omitted]
•Natural polysaccharides are biocompatible, biodegradable, renewable and biologically active.•Cellulose, starch and glycogen are engineered to enrich drug release properties.•It is explored for anticancer drugs delivery, probiotic and cells.•Structural modification increases the bioactivity to several folds.
Natural polysaccharides are renewable with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment. Comprehensive investigations of polysaccharides are essential for our fundamental understanding of exploiting its potential as bio-composite, nano-conjugate and in pharmaceutical sectors. Polysaccharides are considered to be superior to other polymers, for its ease in tailoring, bio-compatibility, bio-activity, homogeneity and bio-adhesive properties. The main focus of this review is to spotlight the new advancements and challenges concerned with surface modification, binding domains, biological interaction with the conjugate including stability, polydispersity, and biodegradability. In this review, we have limited our survey to three essential polysaccharides including cellulose, starch, and glycogen that are sourced from plants, microbes, and animals respectively are reviewed. 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•Natural polysaccharides are biocompatible, biodegradable, renewable and biologically active.•Cellulose, starch and glycogen are engineered to enrich drug release properties.•It is explored for anticancer drugs delivery, probiotic and cells.•Structural modification increases the bioactivity to several folds.
Natural polysaccharides are renewable with a high degree of biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix (ECM) microenvironment. Comprehensive investigations of polysaccharides are essential for our fundamental understanding of exploiting its potential as bio-composite, nano-conjugate and in pharmaceutical sectors. Polysaccharides are considered to be superior to other polymers, for its ease in tailoring, bio-compatibility, bio-activity, homogeneity and bio-adhesive properties. The main focus of this review is to spotlight the new advancements and challenges concerned with surface modification, binding domains, biological interaction with the conjugate including stability, polydispersity, and biodegradability. In this review, we have limited our survey to three essential polysaccharides including cellulose, starch, and glycogen that are sourced from plants, microbes, and animals respectively are reviewed. We also present the polysaccharides which have been extensively modified with the various types of conjugates for combating last-ditch pharmaceutical challenges.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>30086465</pmid><doi>10.1016/j.biopha.2018.07.136</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-7917-8586</orcidid></addata></record> |
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| ispartof | Biomedicine & pharmacotherapy, 2018-11, Vol.107, p.96-108 |
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| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals Antineoplastic Agents - pharmacology Bio-medical applications Cellulose Cellulose - pharmacology Drug Delivery Systems Glycogen Glycogen - pharmacology Natural polysaccharides Polysaccharides - pharmacology Starch Starch - pharmacology |
| title | A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen |
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