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Sensing of L‐Arginine by Gut‐Expressed Calcium Sensing Receptor Stimulates Gut Satiety Hormones Cholecystokinin and Glucose‐Dependent Insulinotropic Peptide Secretion in Pig Model

Nutrients regulate the secretion of gut satiety hormones, which is related to the modulation of food intake and blood glucose levels. Calcium‐sensing receptor (CaSR) is involved in regulating gut hormone secretion in response to l‐amino acids and multivalent cations. Rodents are often used to invest...

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Published in:Journal of food science 2018-09, Vol.83 (9), p.2394-2401
Main Authors: Wang, Chao, Kang, Cuicui, Xian, Yihan, Zhang, Mingyu, Chen, Xiaolin, Pei, Mingcai, Zhu, Weiyun, Hang, Suqin
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cited_by cdi_FETCH-LOGICAL-c3727-e1f2d3c90e6ae17c91e13948188f4fcb2666c0b74523b7c4333bdd8e7aefb2683
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container_title Journal of food science
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creator Wang, Chao
Kang, Cuicui
Xian, Yihan
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Pei, Mingcai
Zhu, Weiyun
Hang, Suqin
description Nutrients regulate the secretion of gut satiety hormones, which is related to the modulation of food intake and blood glucose levels. Calcium‐sensing receptor (CaSR) is involved in regulating gut hormone secretion in response to l‐amino acids and multivalent cations. Rodents are often used to investigate the effect of nutrients on these hormonal release. However, results obtained using rodent models are difficult to be applied in humans, we used pigs as a model in this study because their physiology is similar to that of humans. In this study, we investigated whether l‐Arginine (l‐Arg) could induce gut hormones cholecystokinin (CCK) and glucose‐dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l‐Arg‐regulated gut satiety hormone secretion. Our data showed that treatment with 20 and 50 mM l‐Arg induced CCK and GIP secretion compared with 0 mM l‐Arg. However, treatment with d‐Arg (an inactive isomer) failed to elicit this response. The potency of l‐Arg to induce CCK and GIP secretion was enhanced in the presence of extracellular Ca2+ and CaSR agonist cinacalcet. However, the effect of Arg on CCK and GIP secretion was attenuated by blocking CaSR and its downstream signaling molecules adenylate cyclase (AC) and phospholipase C (PLC). Taken all together, pig duodenum provides an appropriate model to explore the effects of l‐Arg on the secretion of the satiety‐related gut hormones CCK and GIP and the role of CaSR in this effect. Further investigations are needed to verify the effect of l‐Arg on food intake and blood glucose in human study. Practical Application l‐Arginine is able to modulate cholecystokinin and glucose‐dependent insulinotropic peptide secretion through the CaSR in pig model, which has a potential role in regulating food intake and blood glucose levels.
doi_str_mv 10.1111/1750-3841.14297
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Calcium‐sensing receptor (CaSR) is involved in regulating gut hormone secretion in response to l‐amino acids and multivalent cations. Rodents are often used to investigate the effect of nutrients on these hormonal release. However, results obtained using rodent models are difficult to be applied in humans, we used pigs as a model in this study because their physiology is similar to that of humans. In this study, we investigated whether l‐Arginine (l‐Arg) could induce gut hormones cholecystokinin (CCK) and glucose‐dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l‐Arg‐regulated gut satiety hormone secretion. Our data showed that treatment with 20 and 50 mM l‐Arg induced CCK and GIP secretion compared with 0 mM l‐Arg. However, treatment with d‐Arg (an inactive isomer) failed to elicit this response. The potency of l‐Arg to induce CCK and GIP secretion was enhanced in the presence of extracellular Ca2+ and CaSR agonist cinacalcet. However, the effect of Arg on CCK and GIP secretion was attenuated by blocking CaSR and its downstream signaling molecules adenylate cyclase (AC) and phospholipase C (PLC). Taken all together, pig duodenum provides an appropriate model to explore the effects of l‐Arg on the secretion of the satiety‐related gut hormones CCK and GIP and the role of CaSR in this effect. Further investigations are needed to verify the effect of l‐Arg on food intake and blood glucose in human study. Practical Application l‐Arginine is able to modulate cholecystokinin and glucose‐dependent insulinotropic peptide secretion through the CaSR in pig model, which has a potential role in regulating food intake and blood glucose levels.</description><identifier>ISSN: 0022-1147</identifier><identifier>EISSN: 1750-3841</identifier><identifier>DOI: 10.1111/1750-3841.14297</identifier><identifier>PMID: 30088839</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenylate cyclase ; Adenylyl Cyclases - metabolism ; Amino acids ; Animal models ; Animals ; Appetite Regulation - drug effects ; Arginine ; Arginine - pharmacology ; Blood ; Blood glucose ; Blood Glucose - metabolism ; Calcium ; Calcium (blood) ; Calcium (extracellular) ; Calcium - metabolism ; Calcium ions ; Calcium-sensing receptors ; calcium‐sensing receptor ; Cations ; Chemoreception ; Cholecystokinin ; Cholecystokinin - metabolism ; Cinacalcet - pharmacology ; Data processing ; Detection ; Diet ; Duodenum ; Duodenum - drug effects ; Duodenum - metabolism ; Eating - physiology ; Food ; Food intake ; Gastric Inhibitory Polypeptide - metabolism ; Glucose ; glucose‐dependent insulinotropic peptide ; Hormones ; Humans ; Investigations ; Isomerism ; l‐Arginine ; Models, Animal ; Nutrients ; Peptides ; Phospholipase ; Phospholipase C ; porcine duodenum ; Receptors, Calcium-Sensing - metabolism ; Rodents ; Satiation - physiology ; Satiety ; Secretion ; Swine ; Type C Phospholipases - antagonists &amp; inhibitors</subject><ispartof>Journal of food science, 2018-09, Vol.83 (9), p.2394-2401</ispartof><rights>2018 Institute of Food Technologists</rights><rights>2018 Institute of Food Technologists®.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3727-e1f2d3c90e6ae17c91e13948188f4fcb2666c0b74523b7c4333bdd8e7aefb2683</citedby><cites>FETCH-LOGICAL-c3727-e1f2d3c90e6ae17c91e13948188f4fcb2666c0b74523b7c4333bdd8e7aefb2683</cites><orcidid>0000-0001-7906-5365</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30088839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Kang, Cuicui</creatorcontrib><creatorcontrib>Xian, Yihan</creatorcontrib><creatorcontrib>Zhang, Mingyu</creatorcontrib><creatorcontrib>Chen, Xiaolin</creatorcontrib><creatorcontrib>Pei, Mingcai</creatorcontrib><creatorcontrib>Zhu, Weiyun</creatorcontrib><creatorcontrib>Hang, Suqin</creatorcontrib><title>Sensing of L‐Arginine by Gut‐Expressed Calcium Sensing Receptor Stimulates Gut Satiety Hormones Cholecystokinin and Glucose‐Dependent Insulinotropic Peptide Secretion in Pig Model</title><title>Journal of food science</title><addtitle>J Food Sci</addtitle><description>Nutrients regulate the secretion of gut satiety hormones, which is related to the modulation of food intake and blood glucose levels. Calcium‐sensing receptor (CaSR) is involved in regulating gut hormone secretion in response to l‐amino acids and multivalent cations. Rodents are often used to investigate the effect of nutrients on these hormonal release. However, results obtained using rodent models are difficult to be applied in humans, we used pigs as a model in this study because their physiology is similar to that of humans. In this study, we investigated whether l‐Arginine (l‐Arg) could induce gut hormones cholecystokinin (CCK) and glucose‐dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l‐Arg‐regulated gut satiety hormone secretion. Our data showed that treatment with 20 and 50 mM l‐Arg induced CCK and GIP secretion compared with 0 mM l‐Arg. However, treatment with d‐Arg (an inactive isomer) failed to elicit this response. The potency of l‐Arg to induce CCK and GIP secretion was enhanced in the presence of extracellular Ca2+ and CaSR agonist cinacalcet. However, the effect of Arg on CCK and GIP secretion was attenuated by blocking CaSR and its downstream signaling molecules adenylate cyclase (AC) and phospholipase C (PLC). Taken all together, pig duodenum provides an appropriate model to explore the effects of l‐Arg on the secretion of the satiety‐related gut hormones CCK and GIP and the role of CaSR in this effect. Further investigations are needed to verify the effect of l‐Arg on food intake and blood glucose in human study. Practical Application l‐Arginine is able to modulate cholecystokinin and glucose‐dependent insulinotropic peptide secretion through the CaSR in pig model, which has a potential role in regulating food intake and blood glucose levels.</description><subject>Adenylate cyclase</subject><subject>Adenylyl Cyclases - metabolism</subject><subject>Amino acids</subject><subject>Animal models</subject><subject>Animals</subject><subject>Appetite Regulation - drug effects</subject><subject>Arginine</subject><subject>Arginine - pharmacology</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>Calcium</subject><subject>Calcium (blood)</subject><subject>Calcium (extracellular)</subject><subject>Calcium - metabolism</subject><subject>Calcium ions</subject><subject>Calcium-sensing receptors</subject><subject>calcium‐sensing receptor</subject><subject>Cations</subject><subject>Chemoreception</subject><subject>Cholecystokinin</subject><subject>Cholecystokinin - metabolism</subject><subject>Cinacalcet - pharmacology</subject><subject>Data processing</subject><subject>Detection</subject><subject>Diet</subject><subject>Duodenum</subject><subject>Duodenum - drug effects</subject><subject>Duodenum - metabolism</subject><subject>Eating - physiology</subject><subject>Food</subject><subject>Food intake</subject><subject>Gastric Inhibitory Polypeptide - metabolism</subject><subject>Glucose</subject><subject>glucose‐dependent insulinotropic peptide</subject><subject>Hormones</subject><subject>Humans</subject><subject>Investigations</subject><subject>Isomerism</subject><subject>l‐Arginine</subject><subject>Models, Animal</subject><subject>Nutrients</subject><subject>Peptides</subject><subject>Phospholipase</subject><subject>Phospholipase C</subject><subject>porcine duodenum</subject><subject>Receptors, Calcium-Sensing - metabolism</subject><subject>Rodents</subject><subject>Satiation - physiology</subject><subject>Satiety</subject><subject>Secretion</subject><subject>Swine</subject><subject>Type C Phospholipases - antagonists &amp; 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However, the effect of Arg on CCK and GIP secretion was attenuated by blocking CaSR and its downstream signaling molecules adenylate cyclase (AC) and phospholipase C (PLC). Taken all together, pig duodenum provides an appropriate model to explore the effects of l‐Arg on the secretion of the satiety‐related gut hormones CCK and GIP and the role of CaSR in this effect. Further investigations are needed to verify the effect of l‐Arg on food intake and blood glucose in human study. Practical Application l‐Arginine is able to modulate cholecystokinin and glucose‐dependent insulinotropic peptide secretion through the CaSR in pig model, which has a potential role in regulating food intake and blood glucose levels.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30088839</pmid><doi>10.1111/1750-3841.14297</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7906-5365</orcidid></addata></record>
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subjects Adenylate cyclase
Adenylyl Cyclases - metabolism
Amino acids
Animal models
Animals
Appetite Regulation - drug effects
Arginine
Arginine - pharmacology
Blood
Blood glucose
Blood Glucose - metabolism
Calcium
Calcium (blood)
Calcium (extracellular)
Calcium - metabolism
Calcium ions
Calcium-sensing receptors
calcium‐sensing receptor
Cations
Chemoreception
Cholecystokinin
Cholecystokinin - metabolism
Cinacalcet - pharmacology
Data processing
Detection
Diet
Duodenum
Duodenum - drug effects
Duodenum - metabolism
Eating - physiology
Food
Food intake
Gastric Inhibitory Polypeptide - metabolism
Glucose
glucose‐dependent insulinotropic peptide
Hormones
Humans
Investigations
Isomerism
l‐Arginine
Models, Animal
Nutrients
Peptides
Phospholipase
Phospholipase C
porcine duodenum
Receptors, Calcium-Sensing - metabolism
Rodents
Satiation - physiology
Satiety
Secretion
Swine
Type C Phospholipases - antagonists & inhibitors
title Sensing of L‐Arginine by Gut‐Expressed Calcium Sensing Receptor Stimulates Gut Satiety Hormones Cholecystokinin and Glucose‐Dependent Insulinotropic Peptide Secretion in Pig Model
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