Protective effects of α‐bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol‐induced myocardial infarction: In vivo and in vitro evidences

The effect of α‐bisabolol on hemodyanimcs, lipid peroxidation, and nonenzymatic antioxidants was evaluated in isoproterenol‐induced myocardial infarction in rats. They were pre‐ and cotreated with α‐bisabolol (25 mg/kg body weight) daily for 10 days along with the subcutaneous injection of isoproter...

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Published in:Journal of biochemical and molecular toxicology 2018-10, Vol.32 (10), p.e22200-N/A
Main Authors: Meeran, Mohamed Fizur Nagoor, Laham, Farah, Al‐Taee, Hasan, Azimullah, Sheikh, Ojha, Shreesh
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - toxicity
Animal tissues
Animals
Antioxidants
Antioxidants - metabolism
Body weight
Circulatory system
Creatine
Creatine kinase
Creatine Kinase - blood
Creatine Kinase, MB Form - blood
Heart attacks
Hemodynamics
Hemodynamics - drug effects
hemodynamics alterations
In Vitro Techniques
Isoproterenol
Isoproterenol - toxicity
Lipid peroxidation
Lipid Peroxidation - drug effects
Lipids
Male
Myocardial infarction
Myocardial Infarction - chemically induced
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Oxidative Stress - drug effects
Peroxidation
Rats
Rats, Wistar
Recovery of function
Rodents
Sesquiterpenes - pharmacology
α‐bisabolol
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Summary:The effect of α‐bisabolol on hemodyanimcs, lipid peroxidation, and nonenzymatic antioxidants was evaluated in isoproterenol‐induced myocardial infarction in rats. They were pre‐ and cotreated with α‐bisabolol (25 mg/kg body weight) daily for 10 days along with the subcutaneous injection of isoproterenol (85 mg/kg body weight) at an interval of 24 hours for 2 days (9th and 10th days). Increased activities of serum creatine kinase and creatine kinase‐MB along with altered levels/concentrations of lipid peroxidation products and nonenzymatic status were observed in the plasma and heart tissues of rats. Treatment with α‐bisabolol showed protective effects by reversing the altered biochemical parameters and hemodynamics studied. The in vitro reducing power of α‐bisabolol confirmed its potent antioxidant action. These biochemical benefits were translated into functional recovery by the maintenance of the hemodynamics in rats. The findings showed that α‐bisabolol has the potential to protect against isoproterenol‐induced myocardial infarction due to its potent antilipid peroxidation and antioxidant properties.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22200