Warfarin overdose due to the possible effects of Lycium barbarum L

We reported an 80-year-old Chinese woman on chronic stable dose of warfarin who experienced two episodes of an elevated international normalized ratio (INR) after drinking herbal tea containing Lycium barbarum L. Our case illustrated the potential herbal-drug interaction between warfarin and L. barb...

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Bibliographic Details
Published in:Food and chemical toxicology 2008-05, Vol.46 (5), p.1860-1862
Main Authors: Leung, H., Hung, A., Hui, A.C.F., Chan, T.Y.K.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anticoagulants - poisoning
Biological and medical sciences
blood chemistry
case studies
drug interactions
Drug Overdose
elderly
herbal medicines
herbal tea
Humans
International Normalized Ratio
international normalized ratios
Lycium - adverse effects
Lycium barbarum
Lycium barbarum L
Medical sciences
Pesticides, fertilizers and other agrochemicals toxicology
pharmacokinetics
synergism
Toxicology
Warfarin
Warfarin - poisoning
women
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Summary:We reported an 80-year-old Chinese woman on chronic stable dose of warfarin who experienced two episodes of an elevated international normalized ratio (INR) after drinking herbal tea containing Lycium barbarum L. Our case illustrated the potential herbal-drug interaction between warfarin and L. barbarum L. in keeping with a previous case report. Enquiry about herbal intake may be a crucial part in the management of anticoagulation in this locality.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2008.01.008