The clinical and pharmacoeconomic analysis of invasive aspergillosis in adult patients with haematological diseases

Summary Invasive pulmonary aspergillosis (IPA) poses major management problems for clinicians caring for patients with haematological diseases. The clinical courses of patients with IPA who had been hospitalised in Hematology Unit, Bone Marrow Transplantation Unit and Infectious Diseases and Clinica...

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Bibliographic Details
Published in:Mycoses 2008-07, Vol.51 (4), p.328-335
Main Authors: Cagatay, A. Atahan, Cosan, F., Karadeniz, A., Besısık, S. K., Ozsut, H., Nalcaci, M., Pekcelen, Y., Eraksoy, H., Dincol, G., Calangu, S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amphotericin B
Antifungal Agents - adverse effects
Antifungal Agents - economics
Antifungal Agents - therapeutic use
Aspergillosis - drug therapy
Aspergillosis - economics
Aspergillosis - physiopathology
Aspergillus
caspofungin
Drug Costs
Female
Hematologic Diseases - complications
Humans
invasive aspergillosis
Lung Diseases, Fungal - drug therapy
Lung Diseases, Fungal - economics
Lung Diseases, Fungal - physiopathology
Male
Middle Aged
pharmacoeconomic analysis
Retrospective Studies
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Summary:Summary Invasive pulmonary aspergillosis (IPA) poses major management problems for clinicians caring for patients with haematological diseases. The clinical courses of patients with IPA who had been hospitalised in Hematology Unit, Bone Marrow Transplantation Unit and Infectious Diseases and Clinical Microbiology Unit between 1998 and 2005, the efficacy and adverse effects and costs of antifungal drugs (conventional amphotericin B deoxycholate, liposomal amphotericin B, amphotericin B lipid complex and caspofungin) used in the therapy of these patients were analysed in this study. Ninety‐three patients with IPA were reviewed retrospectively. Mean age of the patients was 40.4 ± 15.1 years (range 14–70 years). Fifty‐eight male patients and 35 female patients were included in the study. Manageable hypopotassemia, nausea/vomiting and headache were the most commonly observed side‐effects during antifungal (AF) therapy. While it was not found to be statistically significant with regard to the mean time to resolution of fever (P = 0.8), it was found to be statistically significant with regard to radiological regression at 30th day, and mean duration of therapy between patients who were dead or alive (P 
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2007.01483.x