Patterns of desmin expression in idiopathic dilated cardiomyopathy are related to the desmin mRNA and ubiquitin expression

Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes of desmin mRNA and ubiquitin expression correlate with types of desmin expression in cardiomy...

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Bibliographic Details
Published in:Journal of investigative medicine 2019-01, Vol.67 (1), p.11-19
Main Authors: Pawlak, Agnieszka, Rejmak-Kozicka, Emilia, Gil, Katarzyna Elżbieta, Ziemba, Andrzej, Kaczmarek, Leszek, Gil, Robert Julian
Format: Article
Language:English
Subjects:
Cardiomyocytes
Cardiomyopathy
Cardiomyopathy, Dilated - diagnostic imaging
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - pathology
Desmin - genetics
Desmin - metabolism
Disease
Ejection fraction
Female
Fibrosis
Gene expression
Gene Expression Regulation
Heart failure
Humans
Kinases
Male
Middle Aged
Mutation
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Natriuretic Peptide, Brain - metabolism
Peptide Fragments - metabolism
Proteins
RNA, Messenger - genetics
RNA, Messenger - metabolism
Ubiquitin - genetics
Ubiquitin - metabolism
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Summary:Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes of desmin mRNA and ubiquitin expression correlate with types of desmin expression in cardiomyocytes. Endomyocardial biopsy was performed in 60 patients (85% men, mean age 46±14 years) with heart failure (HF; left ventricular ejection fraction
ISSN:1081-5589
1708-8267
DOI:10.1136/jim-2017-000707