Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass

Peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) is a transcription coactivator that interacts with a broad range of transcription factors involved in several biological responses. Here, we show that PGC1α plays a role in skeletal homeostasis since aged PGC1α-deficient mice (PGC1...

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Bibliographic Details
Published in:Calcified tissue international 2018-12, Vol.103 (6), p.638-652
Main Authors: Colaianni, Graziana, Lippo, Luciana, Sanesi, Lorenzo, Brunetti, Giacomina, Celi, Monica, Cirulli, Nunzio, Passeri, Giovanni, Reseland, Janne, Schipani, Ernestina, Faienza, Maria Felicia, Tarantino, Umberto, Colucci, Silvia, Grano, Maria
Format: Article
Language:English
Subjects:
Anisotropy
Biochemistry
Biomedical and Life Sciences
Bone marrow
Bone mass
Bone resorption
Bone turnover
Cancellous bone
Cell Biology
Clonal deletion
Collagen (type I)
Computed tomography
Cortical bone
Endocrinology
Gene expression
Homeostasis
Life Sciences
Mechanical properties
Mesenchyme
Original Research
Orthopedics
Osteoblastogenesis
Osteocalcin
Rodents
Stem cell transplantation
Stem cells
Transcription factors
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Summary:Peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) is a transcription coactivator that interacts with a broad range of transcription factors involved in several biological responses. Here, we show that PGC1α plays a role in skeletal homeostasis since aged PGC1α-deficient mice (PGC1α −/− ) display impaired bone structure. Micro-CT of the tibial mid-shaft showed a marked decrease of cortical thickness in PGC1α −/− (− 11.9%, p  
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-018-0459-4