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Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner
•Lithium, a mood stabilizer, prevents apoptosis-dependent cellular death and is used to treat various neurological disorders.•At a low dose (10 mg/kg), lithium attenuates susceptibility to and the severity of pilocarpine-induced seizures.•At a higher dose (40 mg/kg), lithium exhibits the opposite ef...
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Published in: | Epilepsy research 2018-10, Vol.146, p.112-120 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Lithium, a mood stabilizer, prevents apoptosis-dependent cellular death and is used to treat various neurological disorders.•At a low dose (10 mg/kg), lithium attenuates susceptibility to and the severity of pilocarpine-induced seizures.•At a higher dose (40 mg/kg), lithium exhibits the opposite effect; this may be related to suppression of gamma oscillation.•The low-dose effect is likely due to increased theta and gamma oscillation and reduced ripple activity.
Lithium, a classic mood stabilizer, prevents apoptosis-dependent cellular death and has garnered considerable interest as a neuroprotective agent that is efficacious in the treatment of many neurological diseases. However, the effects of lithium in epilepsy remain controversial. We found that different doses of lithium affect epileptic seizure activity and bidirectionally modulate the susceptibility to and severity of seizures induced by pilocarpine in rats. Recently, it has been demonstrated that systematically administered lithium affects the powers of hippocampal gamma and theta oscillations in baseline electroencephalograms. Low-dose lithium (10 mg/kg) administered to pilocarpine-treated rats markedly increased the powers of basal gamma (30–80 Hz) and theta (4–12 Hz) oscillations, decreased the proportion of Racine stage 4–5 seizures, extended latency until seizure onset, and significantly reduced the frequency of lower-class seizures (p < 0.05). Conversely, when the dose was increased to 40 mg/kg, lithium reduced the frequency of lower-class seizures compared to control treatment (p |
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ISSN: | 0920-1211 1872-6844 |
DOI: | 10.1016/j.eplepsyres.2018.07.021 |