Interferon-tau stimulated gene expression: A proxy to predict embryonic mortality in dairy cows

The embryonic mortality in cows is a growing concern for an ever-expanding dairy industry. The current study was an attempt to shorten the open period of dairy cows having suffered embryonic loss by diagnosing them at an earlier stage. The blood samples were collected from the Karan Fries (KF) cows...

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Bibliographic Details
Published in:Theriogenology 2018-10, Vol.120, p.61-67
Main Authors: Sheikh, Aasif Ahmad, Hooda, O.K., Kalyan, Ankita, Kamboj, Aarti, Mohammed, Seid, Alhussien, Mohanned, Reddi, Srinu, Shimray, Panreiphy Gachuiwo, Rautela, Ankita, Pandita, Sujata, Kapila, Suman, De, Sachinandan, Dang, A.K.
Format: Article
Language:English
Subjects:
2',5'-Oligoadenylate Synthetase - genetics
2',5'-Oligoadenylate Synthetase - metabolism
Animals
Biomarkers - metabolism
Cattle - embryology
Cattle - genetics
Cattle - metabolism
Cytokines - genetics
Cytokines - metabolism
Dairy cows
Embryonic mortality
Female
Gene expression
Gene Expression Regulation, Developmental
Interferon Type I - blood
Interferon Type I - genetics
Interferon Type I - physiology
Interferon-tau
Myxovirus Resistance Proteins - genetics
Myxovirus Resistance Proteins - metabolism
Neutrophils
Pregnancy
Pregnancy Proteins - blood
Pregnancy Proteins - genetics
Pregnancy Proteins - physiology
Progesterone - blood
RNA, Messenger - metabolism
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Summary:The embryonic mortality in cows is a growing concern for an ever-expanding dairy industry. The current study was an attempt to shorten the open period of dairy cows having suffered embryonic loss by diagnosing them at an earlier stage. The blood samples were collected from the Karan Fries (KF) cows on days 0 (day of AI/estrus), 4, 8, 12, 14, 16, 18, 21, 24, 28, 35 and 42 post insemination. The experimental animals were then categorized into pregnant (P), conception failure/early embryonic mortality (EEM) and late embryonic mortality cows (LEM), based on progesterone assay, ultrasonography and per-rectal palpation. There were 6 animals in each group. The plasma progesterone was higher in pregnant than EEM and LEM cows. Plasma Interferon-tau concentration was significantly (p < 0.05) lower in LEM than pregnant cows where it could be detected from day 14–21 but was non-detectable in EEM cows. The mRNA expression of ISG15, OAS1, MX1 and MX2 in blood neutrophils was significantly (p 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2018.07.028