Anti-HCV positivity in sexual partners and offspring of patient with chronic hepatitis C

We investigated the seroprevalence of HCV in stable sexual partners and offspring of chronic hepatitis C patients, and aimed to determine the risk factors involved. 191 anti-HCV and HCV RNA positive subjects who coinhabited with their spouse and/or offspring were included. Risk factors of index case...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2008, Vol.40 (6-7), p.533-537
Main Authors: Ayk n, Nevil, Cev k, Figen, Dem rturk, Nese, Dem rdal, Tuna, Orhan, Semiha, Naz, Hasan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Family Health
Female
Hepacivirus - isolation & purification
Hepatitis C Antibodies - blood
Hepatitis C virus
Hepatitis C, Chronic - epidemiology
Hepatitis C, Chronic - immunology
Hepatitis C, Chronic - transmission
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
RNA, Viral - blood
Seroepidemiologic Studies
Sexual Partners
Viral diseases
Viral hepatitis
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Summary:We investigated the seroprevalence of HCV in stable sexual partners and offspring of chronic hepatitis C patients, and aimed to determine the risk factors involved. 191 anti-HCV and HCV RNA positive subjects who coinhabited with their spouse and/or offspring were included. Risk factors of index cases for disease transmission, liver biopsy results, anti-HCV and HCV-RNA in spouses and/or offspring were evaluated. Together with index cases, a total of 404 family members including 174 stable sexual partners and 230 offspring were included. The most common risk factors among index cases were dental procedures (73.8%), history of surgery (64.9%), and blood transfusions (24.1%). Anti-HCV positivity was established in 11 (2.7%) of the total 404 family contacts - 6 sexual partners and 5 offspring. HCV seropositivity was significantly higher in the spouses of index cases with severe hepatitis C compared to those with mild to moderate hepatitis C (p = 0.008), but there was no statistically significant correlation between the severity of liver disease in index cases and anti-HCV positivity in their offspring. In conclusion, anti-HCV seropositivity in the spouses and children of patients who are HCV-RNA positive HCV carriers does not appear to be higher than the HCV seroprevalence in our country.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540701867313