The 2,4-D herbicide effects on acetylcholinesterase activity and metabolic parameters of piava freshwater fish ( Leporinus obtusidens)

The effects of 2,4-D (1 or 10 mg/L) on acetylcholinesterase (AChE) and metabolic parameters were evaluated in piava ( Leporinus obtusidens) after 96 h. AChE activity was significantly reduced in the brain at a concentration of 10 mg/L and in the muscle at both concentrations tested. Muscle glycogen...

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Published in:Ecotoxicology and environmental safety 2008-03, Vol.69 (3), p.416-420
Main Authors: da Fonseca, Milene Braga, Glusczak, Lissandra, Silveira Moraes, Bibiana, de Menezes, Charlene Cavalheiro, Pretto, Alexandra, Tierno, Miguel Angel, Zanella, Renato, Gonçalves, Fábio Ferreira, Lúcia Loro, Vânia
Format: Article
Language:English
Subjects:
2,4-Dichlorophenoxyacetic Acid - pharmacology
4-diamin
Acetylcholinesterase - drug effects
Acetylcholinesterase - metabolism
Ache
Animals
Dose-Response Relationship, Drug
Female
Fish
Fishes
Fresh Water
Glucose
Glycogen
Herbicide
Herbicides - pharmacology
Kinetics
Leporinus obtusidens
Liver - drug effects
Liver - enzymology
Male
Muscle, Skeletal - drug effects
Muscle, Skeletal - enzymology
Protein
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Summary:The effects of 2,4-D (1 or 10 mg/L) on acetylcholinesterase (AChE) and metabolic parameters were evaluated in piava ( Leporinus obtusidens) after 96 h. AChE activity was significantly reduced in the brain at a concentration of 10 mg/L and in the muscle at both concentrations tested. Muscle glycogen and lactate were significantly reduced for both 2,4-D concentrations but no significant change was observed in liver glycogen. Muscle protein levels were enhanced after exposure at 10 mg/L, but no significant changes were observed in muscle and liver glucose. Liver lactate and protein were significantly reduced after exposure to this herbicide. 2,4-D exposure produced a decrease in blood glucose at both concentrations and enhanced lactate levels at 10 mg/L. Plasma protein increased at both concentrations tested. In conclusion, the results obtained indicate that 2,4-D affects brain and muscle AChE activity and some blood and tissue metabolic parameters of L. obtusidens. The stress generated by 2,4-D is the probable cause of alterations observed and measured parameters can be used to monitor 2,4-D fish toxicity.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2007.08.006