Influences of mechanical barrier permeability on guided bone augmentation in the rat calvarium

We used radiological and histological analyses to evaluate the effects of mechanical barrier permeability in a rat model of calvarial guided bone augmentation (GBA). The calvaria of 20 rats were exposed, and one of four types of plastic caps (an occlusive cylindrical plastic cap; a plastic cap with...

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Bibliographic Details
Published in:Journal of Oral Science 2018, Vol.60(3), pp.453-459
Main Authors: Yamamoto, Takanobu, Hasuike, Akira, Koshi, Ryosuke, Ozawa, Yasumasa, Ozaki, Manami, Kubota, Tatsuya, Sato, Shuichi
Format: Article
Language:English
Subjects:
alveolar ridge augmentation
Animals
bone regeneration
dental implants
Dentistry
Equipment Design
Guided Tissue Regeneration - instrumentation
Male
Models, Animal
Permeability
Plastics - pharmacology
Rats
Rats, Inbred F344
skull
Skull - diagnostic imaging
Skull - physiology
Staining and Labeling
X-Ray Microtomography
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Summary:We used radiological and histological analyses to evaluate the effects of mechanical barrier permeability in a rat model of calvarial guided bone augmentation (GBA). The calvaria of 20 rats were exposed, and one of four types of plastic caps (an occlusive cylindrical plastic cap; a plastic cap with no top; a plastic cap with three holes; and a plastic cap with four holes) was randomly placed on both sides. Newly generated bone in the plastic caps was evaluated with micro-computed tomography (micro-CT) and histological analysis. Micro-CT volumetric analysis and decalcified hematoxylin and eosin-stained sections showed that GBA barrier permeability was inversely associated with the quantity of augmented bone obtained. Masson’s trichrome staining showed that collagen in newly generated bony tissue was more mature in plastic caps with three holes than in those with more-permeable or more-occlusive barriers. Bone augmentation was inhibited in specimens exhibiting invasion of soft tissue through penetrating holes, and barrier permeability was associated with the quantity of augmented bone developed. In conclusion, moderate barrier permeability is optimal for development of mature augmented bone.
ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.17-0362