Changes in platelet morphology indices in relation to duration of disease and glycemic control in children with type 1 diabetes mellitus

There is limited data on platelet alterations in children with type 1 diabetes mellitus (T1DM). We planned to study the effect of glycemic control and duration of T1DM on platelet morphology in children with T1DM. We conducted an observational study on 260 children; 130 with T1DM (cases) and 130 hea...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2018-09, Vol.32 (9), p.833-838
Main Authors: Venkatesh, Vybhav, Kumar, Rakesh, Varma, Dinesh Kumar, Bhatia, Prateek, Yadav, Jaivinder, Dayal, Devi
Format: Article
Language:English
Subjects:
Age
Blood platelets
Diabetes
Glucose monitoring
Mean platelet volume
Metabolism
Morphology
Mortality
Pediatrics
Platelet distribution width
Platelet large cell ratio
Platelets
Thrombosis
Type 1 diabetes mellitus
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Summary:There is limited data on platelet alterations in children with type 1 diabetes mellitus (T1DM). We planned to study the effect of glycemic control and duration of T1DM on platelet morphology in children with T1DM. We conducted an observational study on 260 children; 130 with T1DM (cases) and 130 healthy controls, in a tertiary care pediatric hospital. Platelet indices including Platelet count (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet-Large cell ratio (P-LCR), Plateletcrit (PCT) were measured, and their means were compared between cases and controls and various subgroups among the cases. The MPV, PDW and P-LCR were significantly higher (p 
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2018.06.008