Prenatal exposure to an environmentally relevant mixture of Canadian Arctic contaminants decreases male reproductive function in an aging rat model

Elevated levels of organochlorines (OC) have been reported in Inuit populations in the Arctic. We hypothesized that prenatal exposure to a Canadian Arctic OC mixture adversely affects male reproductive function and health with age. Sprague–Dawley female rats (F0) were gavaged with an environmentally...

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Bibliographic Details
Published in:Journal of developmental origins of health and disease 2018-10, Vol.9 (5), p.511-518
Main Authors: Maurice, C., Kaczmarczyk, M., Côté, N., Tremblay, Y., Kimmins, S., Bailey, J. L.
Format: Article
Language:English
Subjects:
Adults
Age
Females
Infections
Infertility
Inuit
Males
Men
Original Article
PCB
Pesticides
Polychlorinated biphenyls
Prenatal exposure
Sperm
Weight control
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Summary:Elevated levels of organochlorines (OC) have been reported in Inuit populations in the Arctic. We hypothesized that prenatal exposure to a Canadian Arctic OC mixture adversely affects male reproductive function and health with age. Sprague–Dawley female rats (F0) were gavaged with an environmentally relevant concentration of an Arctic OC mixture or corn oil (Control) during mating with untreated males until parturition (F1 litters). After postnatal day (PND) 90, the weights of the OC F1 males differed dramatically relative to Controls (P
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174418000491