Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines

Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to high titers of IgG antibodies and the express...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (69), p.9655-9658
Main Authors: Wu, Jun-Jun, Li, Wen-Hao, Chen, Pu-Guang, Zhang, Bo-Dou, Hu, Hong-Guo, Li, Qian-Qian, Zhao, Lang, Chen, Yong-Xiang, Zhao, Yu-Fen, Li, Yan-Mei
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - chemical synthesis
Amino Acid Sequence
Animals
Antibiotics
Antibodies
B7-2 Antigen - immunology
Cancer
Cancer vaccines
Cancer Vaccines - immunology
Cancer Vaccines - pharmacology
Cyclic GMP - analogs & derivatives
Cyclic GMP - chemical synthesis
Cyclic GMP - immunology
Cytokines
Cytokines - metabolism
Female
Glycopeptides - chemical synthesis
Glycopeptides - immunology
Humans
Immunity, Cellular - drug effects
Immunity, Humoral - drug effects
Immunoglobulin G - metabolism
Immunoglobulin M - metabolism
Immunotherapy
Macrophage Activation - drug effects
MCF-7 Cells - immunology
Membrane Proteins - agonists
Membrane Proteins - metabolism
Mice
Mice, Inbred BALB C
Mucin-1 - immunology
Peptide Fragments - chemical synthesis
Peptide Fragments - immunology
RAW 264.7 Cells - immunology
Signal Transduction - drug effects
Vaccines
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Summary:Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to high titers of IgG antibodies and the expression of multiple cytokines.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc04860f