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Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines
Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to high titers of IgG antibodies and the express...
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| Published in: | Chemical communications (Cambridge, England) England), 2018, Vol.54 (69), p.9655-9658 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c356t-4a6dbfb223276d7fbd4240a3252b06cecae620de18bb1bf50005c886c215c3bd3 |
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| cites | cdi_FETCH-LOGICAL-c356t-4a6dbfb223276d7fbd4240a3252b06cecae620de18bb1bf50005c886c215c3bd3 |
| container_end_page | 9658 |
| container_issue | 69 |
| container_start_page | 9655 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 54 |
| creator | Wu, Jun-Jun Li, Wen-Hao Chen, Pu-Guang Zhang, Bo-Dou Hu, Hong-Guo Li, Qian-Qian Zhao, Lang Chen, Yong-Xiang Zhao, Yu-Fen Li, Yan-Mei |
| description | Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. CDG in both strategies behaved as a potent immunostimulant and contributed to high titers of IgG antibodies and the expression of multiple cytokines. |
| doi_str_mv | 10.1039/c8cc04860f |
| format | article |
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Li, Wen-Hao ; Chen, Pu-Guang ; Zhang, Bo-Dou ; Hu, Hong-Guo ; Li, Qian-Qian ; Zhao, Lang ; Chen, Yong-Xiang ; Zhao, Yu-Fen ; Li, Yan-Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-4a6dbfb223276d7fbd4240a3252b06cecae620de18bb1bf50005c886c215c3bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adjuvants, Immunologic - chemical synthesis</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Antibodies</topic><topic>B7-2 Antigen - immunology</topic><topic>Cancer</topic><topic>Cancer vaccines</topic><topic>Cancer Vaccines - immunology</topic><topic>Cancer Vaccines - pharmacology</topic><topic>Cyclic GMP - analogs & derivatives</topic><topic>Cyclic GMP - chemical synthesis</topic><topic>Cyclic GMP - immunology</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Female</topic><topic>Glycopeptides - chemical synthesis</topic><topic>Glycopeptides - immunology</topic><topic>Humans</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunity, Humoral - drug effects</topic><topic>Immunoglobulin G - metabolism</topic><topic>Immunoglobulin M - metabolism</topic><topic>Immunotherapy</topic><topic>Macrophage Activation - drug effects</topic><topic>MCF-7 Cells - immunology</topic><topic>Membrane Proteins - agonists</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mucin-1 - immunology</topic><topic>Peptide Fragments - chemical synthesis</topic><topic>Peptide Fragments - immunology</topic><topic>RAW 264.7 Cells - immunology</topic><topic>Signal Transduction - drug effects</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jun-Jun</creatorcontrib><creatorcontrib>Li, Wen-Hao</creatorcontrib><creatorcontrib>Chen, Pu-Guang</creatorcontrib><creatorcontrib>Zhang, Bo-Dou</creatorcontrib><creatorcontrib>Hu, Hong-Guo</creatorcontrib><creatorcontrib>Li, Qian-Qian</creatorcontrib><creatorcontrib>Zhao, Lang</creatorcontrib><creatorcontrib>Chen, Yong-Xiang</creatorcontrib><creatorcontrib>Zhao, Yu-Fen</creatorcontrib><creatorcontrib>Li, Yan-Mei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jun-Jun</au><au>Li, Wen-Hao</au><au>Chen, Pu-Guang</au><au>Zhang, Bo-Dou</au><au>Hu, Hong-Guo</au><au>Li, Qian-Qian</au><au>Zhao, Lang</au><au>Chen, Yong-Xiang</au><au>Zhao, Yu-Fen</au><au>Li, Yan-Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2018</date><risdate>2018</risdate><volume>54</volume><issue>69</issue><spage>9655</spage><epage>9658</epage><pages>9655-9658</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Cyclic di-GMP (CDG) was applied to MUC1 glycopeptide-based cancer vaccines with physical mixing and built-in (at 2'-OH of CDG) strategies for activating the STING pathway. 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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2018, Vol.54 (69), p.9655-9658 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2087998617 |
| source | Royal Society of Chemistry |
| subjects | Adjuvants, Immunologic - chemical synthesis Amino Acid Sequence Animals Antibiotics Antibodies B7-2 Antigen - immunology Cancer Cancer vaccines Cancer Vaccines - immunology Cancer Vaccines - pharmacology Cyclic GMP - analogs & derivatives Cyclic GMP - chemical synthesis Cyclic GMP - immunology Cytokines Cytokines - metabolism Female Glycopeptides - chemical synthesis Glycopeptides - immunology Humans Immunity, Cellular - drug effects Immunity, Humoral - drug effects Immunoglobulin G - metabolism Immunoglobulin M - metabolism Immunotherapy Macrophage Activation - drug effects MCF-7 Cells - immunology Membrane Proteins - agonists Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mucin-1 - immunology Peptide Fragments - chemical synthesis Peptide Fragments - immunology RAW 264.7 Cells - immunology Signal Transduction - drug effects Vaccines |
| title | Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines |
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