The multi-dimensional role of intestinal HIFs in liver pathobiology

Ouyang and Mehal discuss a study by Shao and colleagues which offered convincing evidence for an important role of HIF-1α in liver pathobiology. The study address the discrete hypothesis that HIF-1α is required for the physiological adaptation to excess alcohol consumption by transcriptional regulat...

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Bibliographic Details
Published in:Journal of hepatology 2018-10, Vol.69 (4), p.772-773
Main Authors: Ouyang, Xinshou, Mehal, Wajahat Z.
Format: Article
Language:English
Subjects:
Alcohol
Alcohol use
Basic Helix-Loop-Helix Transcription Factors
Dysbiosis
Gene regulation
Humans
Intestine
Lipogenesis
Liver
Liver diseases
Liver Diseases, Alcoholic
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Summary:Ouyang and Mehal discuss a study by Shao and colleagues which offered convincing evidence for an important role of HIF-1α in liver pathobiology. The study address the discrete hypothesis that HIF-1α is required for the physiological adaptation to excess alcohol consumption by transcriptional regulation of intestinal epithelial genes involved in homeostatic responses, including hepatic lipogenesis, maintenance of intestinal barrier function, antimicrobial defense, and the normal microbiome. Their important finding demonstrates a clear adaptive role of intestinal epithelial HIF-1α to alcohol. It also raises clear questions of the relative roles of the closely related HIF-1α and HIF-2α.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2018.07.012