Different types, applications and limits of enabling excipients of pharmaceutical dosage forms

Along with the development of novel drug delivery systems the material science is also advancing. Conventional and novel synthetic or natural excipients provide opportunities to design dosage forms of the required features including their bioavailability. Emerging trends in the design and developmen...

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Bibliographic Details
Published in:Drug discovery today. Technologies 2018-07, Vol.27, p.21-39
Main Authors: Palcsó, Barnabás, Zelkó, Romána
Format: Article
Language:English
Subjects:
Dosage Forms
Drug Design
Excipients - chemistry
Hydrophobic and Hydrophilic Interactions
Solubility
Surface-Active Agents - chemistry
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Description
Summary:Along with the development of novel drug delivery systems the material science is also advancing. Conventional and novel synthetic or natural excipients provide opportunities to design dosage forms of the required features including their bioavailability. Emerging trends in the design and development of drug products indicate an increasing need for the functionality-related characterization of excipients. The purpose of this review is to provide an overview of different types of excipients in relation to their application possibilities in various dosage forms with special focus on the enabling excipients. The study also summarizes the applied excipient systems of research formulations and dosage forms available on the market.
ISSN:1740-6749
1740-6749
DOI:10.1016/j.ddtec.2018.04.002