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Sub-chronic low dose γ-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine
gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism. Given its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated w...
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| Published in: | Psychopharmacologia 2003-07, Vol.168 (3), p.339-343 |
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| Language: | English |
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| container_end_page | 343 |
| container_issue | 3 |
| container_start_page | 339 |
| container_title | Psychopharmacologia |
| container_volume | 168 |
| creator | SCHIFFER, Wynne K MARSTELLER, Douglas DEWEY, Stephen L |
| description | gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism.
Given its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA).
Using in vivo microdialysis, we compared acute exposure (450 mg/kg) to an identical sub-chronic exposure (150 mg/kg per day for 3 days), followed by 1- or 3-day washout. Finally, we examined the low dose of 150 mg/kg (50 mg/kg per day) using a similar washout period.
Sub-chronic GVG exposure inhibited the effect of cocaine for 3 days, which exceeded in magnitude and duration the identical acute dose.
Sub-chronic low dose GVG potentiates and extends the inhibition of cocaine-induced increases in dopamine, effectively reducing cumulative exposures and the risk for VFDS. |
| doi_str_mv | 10.1007/s00213-003-1446-6 |
| format | article |
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Given its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA).
Using in vivo microdialysis, we compared acute exposure (450 mg/kg) to an identical sub-chronic exposure (150 mg/kg per day for 3 days), followed by 1- or 3-day washout. Finally, we examined the low dose of 150 mg/kg (50 mg/kg per day) using a similar washout period.
Sub-chronic GVG exposure inhibited the effect of cocaine for 3 days, which exceeded in magnitude and duration the identical acute dose.
Sub-chronic low dose GVG potentiates and extends the inhibition of cocaine-induced increases in dopamine, effectively reducing cumulative exposures and the risk for VFDS.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-003-1446-6</identifier><identifier>PMID: 12684739</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>4-Aminobutyrate Transaminase - antagonists & inhibitors ; Addictive behaviors ; Adult and adolescent clinical studies ; Animals ; Biological and medical sciences ; Cocaine - pharmacology ; Cocaine-Related Disorders - drug therapy ; Dopamine - metabolism ; Dose-Response Relationship, Drug ; Drug addiction ; Male ; Medical sciences ; Microdialysis ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Vigabatrin - administration & dosage ; Vigabatrin - pharmacology</subject><ispartof>Psychopharmacologia, 2003-07, Vol.168 (3), p.339-343</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14991926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12684739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHIFFER, Wynne K</creatorcontrib><creatorcontrib>MARSTELLER, Douglas</creatorcontrib><creatorcontrib>DEWEY, Stephen L</creatorcontrib><title>Sub-chronic low dose γ-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism.
Given its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA).
Using in vivo microdialysis, we compared acute exposure (450 mg/kg) to an identical sub-chronic exposure (150 mg/kg per day for 3 days), followed by 1- or 3-day washout. Finally, we examined the low dose of 150 mg/kg (50 mg/kg per day) using a similar washout period.
Sub-chronic GVG exposure inhibited the effect of cocaine for 3 days, which exceeded in magnitude and duration the identical acute dose.
Sub-chronic low dose GVG potentiates and extends the inhibition of cocaine-induced increases in dopamine, effectively reducing cumulative exposures and the risk for VFDS.</description><subject>4-Aminobutyrate Transaminase - antagonists & inhibitors</subject><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cocaine - pharmacology</subject><subject>Cocaine-Related Disorders - drug therapy</subject><subject>Dopamine - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug addiction</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microdialysis</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Time Factors</subject><subject>Vigabatrin - administration & dosage</subject><subject>Vigabatrin - pharmacology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpFkM9KAzEQh4MotlYfwIvkoughOvnTbHKsRatQ8KCel2yatZHd7LrZrfS5fA-fyYAV5zIzfB8_hkHolMI1BchuIgCjnABwQoWQRO6hMRWcEQYZ20fjBDjhdKpG6CjGd0gllDhEI8qkEhnXY9Q-DwWx664J3uKq-cSrJjr8_UU2PmwrvJjdzvDlxr-ZwvSdD1fYh7UvfB-xbazxwREfVoN1qwRs50x0MU04DLZyQ8TG2qEuXIgptzV18o_RQWmq6E52fYJe7-9e5g9k-bR4nM-WpE239YQ6RulUMlaWAEo6rZiU3Jois2B0WiUkpCV3utQCChBCaQeC68KqrCz5BF385rZd8zG42Oe1j9ZVlQmuGWLOQCnBBU_i2U4citqt8rbztem2-d-PknC-E0y0pio7E6yP_57Qmmom-Q8_lHah</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>SCHIFFER, Wynne K</creator><creator>MARSTELLER, Douglas</creator><creator>DEWEY, Stephen L</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope></search><sort><creationdate>20030701</creationdate><title>Sub-chronic low dose γ-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine</title><author>SCHIFFER, Wynne K ; MARSTELLER, Douglas ; DEWEY, Stephen L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p268t-1e2115622ff0086e982663cab7c0a9e98602ff963e9f940b04489e0439bc87ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>4-Aminobutyrate Transaminase - antagonists & inhibitors</topic><topic>Addictive behaviors</topic><topic>Adult and adolescent clinical studies</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cocaine - pharmacology</topic><topic>Cocaine-Related Disorders - drug therapy</topic><topic>Dopamine - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug addiction</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microdialysis</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><topic>Vigabatrin - administration & dosage</topic><topic>Vigabatrin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHIFFER, Wynne K</creatorcontrib><creatorcontrib>MARSTELLER, Douglas</creatorcontrib><creatorcontrib>DEWEY, Stephen L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHIFFER, Wynne K</au><au>MARSTELLER, Douglas</au><au>DEWEY, Stephen L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sub-chronic low dose γ-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>168</volume><issue>3</issue><spage>339</spage><epage>343</epage><pages>339-343</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism.
Given its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA).
Using in vivo microdialysis, we compared acute exposure (450 mg/kg) to an identical sub-chronic exposure (150 mg/kg per day for 3 days), followed by 1- or 3-day washout. Finally, we examined the low dose of 150 mg/kg (50 mg/kg per day) using a similar washout period.
Sub-chronic GVG exposure inhibited the effect of cocaine for 3 days, which exceeded in magnitude and duration the identical acute dose.
Sub-chronic low dose GVG potentiates and extends the inhibition of cocaine-induced increases in dopamine, effectively reducing cumulative exposures and the risk for VFDS.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12684739</pmid><doi>10.1007/s00213-003-1446-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Psychopharmacologia, 2003-07, Vol.168 (3), p.339-343 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| subjects | 4-Aminobutyrate Transaminase - antagonists & inhibitors Addictive behaviors Adult and adolescent clinical studies Animals Biological and medical sciences Cocaine - pharmacology Cocaine-Related Disorders - drug therapy Dopamine - metabolism Dose-Response Relationship, Drug Drug addiction Male Medical sciences Microdialysis Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Time Factors Vigabatrin - administration & dosage Vigabatrin - pharmacology |
| title | Sub-chronic low dose γ-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine |
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