The micronucleus test in piscine erythrocytes

Cytogenetic assays on aquatic organisms are essential, as humans are exposed throughout their lifetime to several xenobiotics present in both the water and aquatic food. The micronucleus test showed to be a useful in vivo assay for genotoxicity testing. However, many aspects of its protocol need to...

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Bibliographic Details
Published in:Aquatic toxicology 2006-08, Vol.79 (2), p.201-204
Main Author: Udroiu, Ion
Format: Article
Language:English
Subjects:
animal tissues
Animal, plant and microbial ecology
Animals
Applied ecology
bioassays
Biological and medical sciences
cell nucleus
cytogenetic analysis
Ecotoxicology, biological effects of pollution
erythrocytes
Erythrocytes - drug effects
erythropoiesis
Erythropoiesis - drug effects
experimental design
fish
Fishes - blood
Fundamental and applied biological sciences. Psychology
General aspects
Genotoxicity
literature reviews
Micronucleus test
Micronucleus Tests - methods
Micronucleus Tests - standards
mutagenesis
toxicity testing
Water Pollutants, Chemical - toxicity
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Summary:Cytogenetic assays on aquatic organisms are essential, as humans are exposed throughout their lifetime to several xenobiotics present in both the water and aquatic food. The micronucleus test showed to be a useful in vivo assay for genotoxicity testing. However, many aspects of its protocol need to be refined, knowledge of confounding factors should be improved and inter-species differences need further investigation. This review summarizes the protocols developed until now, provides knowledge from hematology and physiology that might be useful to researchers dealing with the micronucleus test and indicates the drawbacks of this assay.
ISSN:0166-445X
1879-1514
DOI:10.1016/j.aquatox.2006.06.013