Regulation of IL-1 signaling by the decoy receptor IL-1R2

The pleiotropic cytokine IL-1 mediates its biological functions via association with the signaling receptor IL-1R1. Despite an apparent simplicity in IL-1 signaling activation, multiple negative regulators have been identified. The decoy receptor IL-1R2 (also known as CD121b) can suppress IL-1 matur...

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Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2018-10, Vol.96 (10), p.983-992
Main Authors: Schlüter, Thomas, Schelmbauer, Carsten, Karram, Khalad, Mufazalov, Ilgiz A.
Format: Article
Language:English
Subjects:
Adapter proteins
Binding sites
Biomedical and Life Sciences
Biomedicine
Competition
Cytokines
Human Genetics
Immune response
Inflammation
Interleukin 1
Interleukin 1 receptors
Internal Medicine
Kinases
Molecular Medicine
Regulation
Review
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Summary:The pleiotropic cytokine IL-1 mediates its biological functions via association with the signaling receptor IL-1R1. Despite an apparent simplicity in IL-1 signaling activation, multiple negative regulators have been identified. The decoy receptor IL-1R2 (also known as CD121b) can suppress IL-1 maturation, sequester its active forms or hinder the signaling complex assembly. IL-1R2 is differentially expressed among numerous cell types and displays cis - and trans - modes of action. In this review, we link different forms of IL-1R2 (membrane-bound (mIL-1R2), secreted (sIL-1R2), shedded (shIL-1R2), cytoplasmic, and intracellular domain (IL-1R2 ICD ) restricted) with their ability to interfere with IL-1, thereby regulating immune responses. We also discuss the intriguing possible function of IL-1R2 as a transcriptional regulator. Finally, we summarize the known impact of IL-1R2 in disease pathogenesis and discuss its potential role in treatment of inflammatory conditions.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-018-1684-z