Anatomical Optical Coherence Tomography for Long-Term, Portable, Quantitative Endoscopy

In this paper, we report on anatomical optical coherence tomography, a catheter-based optical modality designed to provide quantitative sectional images of internal hollow organ anatomy over extended observational periods. We consider the design and performance of an instrument and its initial inten...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2008-04, Vol.55 (4), p.1438-1446
Main Authors: Leigh, Matthew S., Armstrong, Julian J., Paduch, Alexandre, Walsh, Jennifer H., Hillman, David R., Eastwood, Peter R., Sampson, David D.
Format: Article
Language:English
Subjects:
Anatomy
Biomedical optical imaging
Endoscopes
endoscopy
Equipment Design
Equipment Failure Analysis
Humans
Imaging, Three-Dimensional - instrumentation
Instruments
Laryngoscopes
optical coherence tomography
Optical design
Optical imaging
Reproducibility of Results
Safety
Sensitivity and Specificity
Shape
Sleep apnea
Sleep Apnea, Obstructive - pathology
Tomography
Tomography, Optical Coherence - instrumentation
upper airway
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Summary:In this paper, we report on anatomical optical coherence tomography, a catheter-based optical modality designed to provide quantitative sectional images of internal hollow organ anatomy over extended observational periods. We consider the design and performance of an instrument and its initial intended application in the human upper airway for the characterization of obstructive sleep apnea (OSA). Compared with current modalities, the technique uniquely combines quantitative imaging, bedside operation, and safety for use over extended periods of time with no cumulative dose limit. Our experiments show that the instrument is capable of imaging subjects during sleep, and that it can record dynamic changes in airway size and shape.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2007.913409