Experimental Application of Organic-Inorganic Hybrid Coatings with Adsorbed Bacteriophages for Reducing the Risk of STEC Infections

A new approach to prevention of STEC infection is based on the synergic effect of combined bactericidal activity of bacteriophages and organic-inorganic hybrid coating of metals. The coatings are characterized by superhydrophilic or superhydrophobic properties and multimodal granularity with the tex...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-08, Vol.165 (4), p.478-481
Main Authors: Aleshkin, A. V., Zulkarneev, E. R., Kiseleva, I. A., Emelyanenko, K. A., Emelyanenko, A. M., Boinovich, L. B.
Format: Article
Language:English
Subjects:
Antibacterial agents
Bacteriophages - physiology
Biomedical and Life Sciences
Biomedicine
Care and treatment
Cell Biology
Coated Materials, Biocompatible - therapeutic use
Coatings
Escherichia coli
Escherichia coli Infections - prevention & control
Hydrophobic and Hydrophilic Interactions
Immunology and Microbiology
Infection
Internal Medicine
Laboratory Medicine
Pathology
Risk factors
Shiga-Toxigenic Escherichia coli - pathogenicity
Von Willebrand factor
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Summary:A new approach to prevention of STEC infection is based on the synergic effect of combined bactericidal activity of bacteriophages and organic-inorganic hybrid coating of metals. The coatings are characterized by superhydrophilic or superhydrophobic properties and multimodal granularity with the texture incorporating metal oxide nanoparticles and bacteriophages. Superhydrophilic surfaces are characterized by significantly higher bactericidal activity than superhydrophobic ones. The cytotoxicity of superhydrophobic surfaces can be increased due to antibacterial activity of bacteriophages combined with the superhydrophobic characteristics of the materials.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4198-3