Acute exacerbation of hepatitis due to reactivation of hepatitis B virus with mutations in the core region after chemotherapy for malignant lymphoma

A 43-year-old Japanese man who was positive for hepatitis B surface (HBs) antigen and HB e antibody, underwent chemotherapy for non-Hodgkin's lymphoma. After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-a...

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Bibliographic Details
Published in:Journal of gastroenterology 1997-10, Vol.32 (5), p.668-671
Main Authors: Sato, T, Kato, J, Kawanishi, J, Kogawa, K, Ohya, M, Sakamaki, S, Niitsu, Y
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Antigenicity
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biopsy
Chemotherapy
Codons
Cyclophosphamide - adverse effects
Cyclophosphamide - therapeutic use
Cytotoxicity
DNA Primers - chemistry
DNA, Viral - analysis
Doxorubicin - adverse effects
Doxorubicin - therapeutic use
Follow-Up Studies
Glucagon
Glucosinolates - immunology
Hepatitis B
Hepatitis B - etiology
Hepatitis B - pathology
Hepatitis B Antibodies - analysis
Hepatitis B Core Antigens - drug effects
Hepatitis B Core Antigens - genetics
Hepatitis B virus
Hepatitis B virus - drug effects
Hepatitis B virus - genetics
Hepatitis B virus - growth & development
Humans
Insulin
Lymphocytes T
Lymphoma, Non-Hodgkin - drug therapy
Male
Mutation
Mutation - genetics
Non-Hodgkin's lymphoma
Polymerase Chain Reaction
Prednisone - adverse effects
Prednisone - therapeutic use
Vincristine - adverse effects
Vincristine - therapeutic use
Virus Activation - drug effects
α-Interferon
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Description
Summary:A 43-year-old Japanese man who was positive for hepatitis B surface (HBs) antigen and HB e antibody, underwent chemotherapy for non-Hodgkin's lymphoma. After the chemotherapy he suffered from acute exacerbation of hepatitis because of reactivation of HBV. Recovery was achieved with interferon-alpha, glucagon-insulin therapy, and plasma exchange. Mutations were detected in codons 97, 100, 129, and 131 of the core region of HBV. The peptide encoded from the core region including such mutations possibly had greater antigenicity to induce cytotoxic T cell activity in the host. Core region mutations may be a crucial cause of the acute exacerbation of hepatitis B seen after chemotherapy.
ISSN:0944-1174
1435-5922
DOI:10.1007/BF02934119