Desmopressin/indomethacin combination efficacy and safety in renal colic pain management: A randomized placebo controlled trial

Renal colic is a prevalent cause of abdominal pain in the emergency department. Although non-steroidal anti-inflammatory drugs and opioids are used for the treatment of renal colic, some adverse effects have been reported. Therefore, desmopressin -a synthetic analogue of vasopressin- has been propos...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of emergency medicine 2019-06, Vol.37 (6), p.1009-1012
Main Authors: Jalili, Mohammad, Shirani, Farzaneh, Entezari, Pouya, Hedayatshodeh, Mohammadreza, Baigi, Vali, Mirfazaelian, Hadi
Format: Article
Language:English
Subjects:
Adult
Analgesics
Anaphylaxis
Anti-inflammatory agents
Chi-Square Distribution
Clinical trials
Deamino Arginine Vasopressin - standards
Deamino Arginine Vasopressin - therapeutic use
Desmopressin
Double-Blind Method
Drug Combinations
Drug dosages
Dyspnea
Emergency medical care
Emergency medical services
Evidence-based medicine
Female
Humans
Indomethacin
Indomethacin - standards
Indomethacin - therapeutic use
Inflammation
Kidneys
Male
Middle Aged
Narcotics
Nonsteroidal anti-inflammatory drugs
Opioids
Pain
Pain - drug therapy
Pain management
Pain Management - methods
Pain Management - standards
Pain Management - statistics & numerical data
Pain Measurement - methods
Patient Safety - standards
Patient Safety - statistics & numerical data
Patients
Placebos
Prospective Studies
Randomization
Renal colic
Renal Colic - complications
Renal Colic - drug therapy
Renal Colic - psychology
Ulcers
Vasopressin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Renal colic is a prevalent cause of abdominal pain in the emergency department. Although non-steroidal anti-inflammatory drugs and opioids are used for the treatment of renal colic, some adverse effects have been reported. Therefore, desmopressin -a synthetic analogue of vasopressin- has been proposed as another treatment choice. In the present study, indomethacin in combination with nasal desmopressin was compared with indomethacin alone in the management of renal colic. Included in the study were 124 patients with initial diagnosis of renal colic and randomized to receive indomethacin suppository (100 mg) with either desmopressin intranasal spray (4 puffs, total dose of 40 micrograms) and or placebo intranasal spray. All the included patients were finally diagnosed with renal colic. There was no difference between the two groups in pain at the baseline (p = 0.4) and both treatments reduced pain successfully (p 
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2018.08.033