GDNF and GFRα: a versatile molecular complex for developing neurons

The GDNF family ligands (GFLs) signal through the canonical signaling receptor Ret and a glycosyl-phosphatidylinositol-anchored co-receptor, GFRα. In recent years, signaling by GFLs has been shown to be more complex than originally assumed. The discrepant expression between GFRαs and Ret has suggest...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2008-08, Vol.31 (8), p.384-391
Main Authors: Paratcha, Gustavo, Ledda, Fernanda
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Neurology
Olfactory system and olfaction. Gustatory system and gustation
Vertebrates: nervous system and sense organs
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Summary:The GDNF family ligands (GFLs) signal through the canonical signaling receptor Ret and a glycosyl-phosphatidylinositol-anchored co-receptor, GFRα. In recent years, signaling by GFLs has been shown to be more complex than originally assumed. The discrepant expression between GFRαs and Ret has suggested the existence of additional signal-transducing GDNF receptors, such as NCAM. Here we summarize novel functions and Ret-independent signaling mechanisms for GDNF and GFRα, focusing on developing neurons. Emerging evidence indicates a prominent role of GDNF and GFRα in the control of neuroblast migration and chemoattraction and in the formation of neuronal synapses by a new mechanism of ligand-induced cell adhesion. Therefore, these data highlight the importance of this versatile molecular complex for nervous system development, function and regeneration.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2008.05.003