Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease

Cardiovascular complications, as the main cause of mortality in renal patients, are followed with altered lipoproteins composition. Considering that paraoxonase-1 (PON1) is an anti-oxidative enzyme located mainly on HDL particles, the current study has aim to investigate whether failure of kidney fu...

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Bibliographic Details
Published in:Clinical biochemistry 2018-09, Vol.60, p.52-58
Main Authors: Miljkovic, Milica, Stefanovic, Aleksandra, Vekic, Jelena, Zeljkovic, Aleksandra, Gojkovic, Tamara, Simic-Ogrizovic, Sanja, Bogavac-Stanojevic, Natasa, Cerne, Darko, Ilic, Jasmina, Stefanovic, Ivan, Jelic-Ivanovic, Zorana, Spasojevic-Kalimanovska, Vesna, Kotur-Stevuljevic, Jelena
Format: Article
Language:English
Subjects:
Dyslipidaemia
HDL subclasses
Paraoxonase-1
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Summary:Cardiovascular complications, as the main cause of mortality in renal patients, are followed with altered lipoproteins composition. Considering that paraoxonase-1 (PON1) is an anti-oxidative enzyme located mainly on HDL particles, the current study has aim to investigate whether failure of kidney function leads to changes in the distribution of PON1 activity between different HDL subclasses. In 77 renal patients (21 chronic kidney disease (CKD) and 56 end stage renal disease (ESRD) patients on dialysis) and 20 healthy subjects PON1 activity on HDL2 and HDL3 subclasses was determined by zymogram method that combines gradient gel electrophoresis separation of HDL subclasses and measurement of PON1 activity in the same gel. Serum paraoxonase (p
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2018.08.006