Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats

The influence of melatonin, curcumin, quercetin, and resveratrol pretreatment on ferric nitrilotriacetate (Fe-NTA)-induced oxidative renal damage was studied. Male Wistar rats were treated orally once daily for 3 days with melatonin (10 mg/kg), curcumin (50 mg/kg), quercetin (15 mg/kg), and resverat...

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Published in:Human & experimental toxicology 2008-04, Vol.27 (4), p.347-353
Main Authors: Eybl, V, Kotyzová, D, Černá, P, Koutenský, J
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - pharmacology
Biological and medical sciences
Blood Urea Nitrogen
Carcinogenesis, carcinogens and anticarcinogens
Catalase - metabolism
Chemical agents
Chemicals
Curcumin - pharmacology
Disease Models, Animal
Ferric Compounds - toxicity
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Kidney Diseases - chemically induced
Kidney Diseases - metabolism
Kidney Diseases - prevention & control
Kidneys
Lipid Peroxidation
Male
Medical sciences
Melatonin - pharmacology
Metals, Heavy - metabolism
Nitrilotriacetic Acid - analogs & derivatives
Nitrilotriacetic Acid - toxicity
Organ Size - drug effects
Oxidation
Oxidative Stress
Poisoning
Quercetin - pharmacology
Rats
Rats, Wistar
Rodents
Stilbenes - pharmacology
Toxicology
Tumors
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Summary:The influence of melatonin, curcumin, quercetin, and resveratrol pretreatment on ferric nitrilotriacetate (Fe-NTA)-induced oxidative renal damage was studied. Male Wistar rats were treated orally once daily for 3 days with melatonin (10 mg/kg), curcumin (50 mg/kg), quercetin (15 mg/kg), and resveratrol (10 mg/kg). One hour after the last dose of antioxidants, a single dose of Fe-NTA was administered (8 mg of Fe/kg body weight, i.p.) to pre-treated animals. Twenty-four hours after Fe-NTA administration, the lipid peroxidation (LP), reduced glutathione (GSH), catalase (CAT), and glutathione peroxidase (GSH-Px) were estimated in kidney homogenates. Iron, zinc, and copper concentrations were estimated in kidney tissue. Administration of Fe-NTA to rats induced renal LP (170%, P 
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327108094508