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Fluorotelomer alcohols induce hepatic vitellogenin through activation of the estrogen receptor in male medaka (Oryzias latipes)

Here we report on the in vivo estrogenic effects of two fluorotelomer alcohols, such as 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) and 1H,1H,2H,2H-perfluorodecan-1-ol (8:2 FTOH), in male medaka (Oryzias latipes). An in vitro yeast two-hybrid assay indicated a significant, dose-dependent interaction...

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Published in:Chemosphere (Oxford) 2008-05, Vol.71 (10), p.1853-1859
Main Authors: Ishibashi, Hiroshi, Yamauchi, Ryoko, Matsuoka, Munekazu, Kim, Joon-Woo, Hirano, Masashi, Yamaguchi, Akemi, Tominaga, Nobuaki, Arizono, Koji
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description Here we report on the in vivo estrogenic effects of two fluorotelomer alcohols, such as 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) and 1H,1H,2H,2H-perfluorodecan-1-ol (8:2 FTOH), in male medaka (Oryzias latipes). An in vitro yeast two-hybrid assay indicated a significant, dose-dependent interaction between medaka estrogen receptor α (ERα) and coactivator TIF2 upon treatment with 6:2 FTOH, 8:2 FTOH or 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluoro-1-decanol (NFDH). The relative ranks of tested chemicals on the estrogenic effects for medaka ERα descended in the order of estradiol-17β (100)≫6:2 FTOH (0.16)>NFDH (0.016)>8:2 FTOH (0.0044). In contrast, no interaction with the ERα was observed upon treatment with perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorododecanoic acid (PFDA) or perfluoroundecanoic acid (PFUnDA). Expression analysis of hepatic vitellogenin (VTG) protein showed estrogenic potentials with, 6:2 FTOH and 8:2 FTOH, indicative of the induction of VTG synthesis in the livers of male medaka. We also investigated mRNA expression levels of two ER subtypes (ERα and β) and two VTGs (VTG I and VTG II) in the livers of male medaka following exposure to FTOHs. Quantitative real-time polymerase chain reaction analyses revealed that hepatic ERα, VTG I, and VTG II mRNA responded rapidly to FTOHs such as 6:2 FTOH and 8:2 FTOH after 8-h exposure, whereas no effects of these compounds on ERβ mRNA transcription were observed. These results from both in vitro and in vivo assays strongly suggest that certain FTOHs, such as 6:2 FTOH and 8:2 FTOH, induce hepatic VTG through activation of ERα in male medaka.
doi_str_mv 10.1016/j.chemosphere.2008.01.065
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An in vitro yeast two-hybrid assay indicated a significant, dose-dependent interaction between medaka estrogen receptor α (ERα) and coactivator TIF2 upon treatment with 6:2 FTOH, 8:2 FTOH or 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluoro-1-decanol (NFDH). The relative ranks of tested chemicals on the estrogenic effects for medaka ERα descended in the order of estradiol-17β (100)≫6:2 FTOH (0.16)&gt;NFDH (0.016)&gt;8:2 FTOH (0.0044). In contrast, no interaction with the ERα was observed upon treatment with perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorododecanoic acid (PFDA) or perfluoroundecanoic acid (PFUnDA). Expression analysis of hepatic vitellogenin (VTG) protein showed estrogenic potentials with, 6:2 FTOH and 8:2 FTOH, indicative of the induction of VTG synthesis in the livers of male medaka. 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Psychology ; General aspects ; Liver - drug effects ; Liver - metabolism ; Male ; Oryzias - metabolism ; Oryzias latipes ; Receptors, Estrogen - genetics ; RNA, Messenger - metabolism ; Saccharomyces cerevisiae - genetics ; Synecology ; Vitellogenin ; Vitellogenins - genetics ; Water Pollutants, Chemical - toxicity</subject><ispartof>Chemosphere (Oxford), 2008-05, Vol.71 (10), p.1853-1859</ispartof><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-8bb6a87dbb21819128b3b77669ad5104bd9115572b00d78d4679670aa75164dd3</citedby><cites>FETCH-LOGICAL-c502t-8bb6a87dbb21819128b3b77669ad5104bd9115572b00d78d4679670aa75164dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20310423$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18334264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishibashi, Hiroshi</creatorcontrib><creatorcontrib>Yamauchi, Ryoko</creatorcontrib><creatorcontrib>Matsuoka, Munekazu</creatorcontrib><creatorcontrib>Kim, Joon-Woo</creatorcontrib><creatorcontrib>Hirano, Masashi</creatorcontrib><creatorcontrib>Yamaguchi, Akemi</creatorcontrib><creatorcontrib>Tominaga, Nobuaki</creatorcontrib><creatorcontrib>Arizono, Koji</creatorcontrib><title>Fluorotelomer alcohols induce hepatic vitellogenin through activation of the estrogen receptor in male medaka (Oryzias latipes)</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>Here we report on the in vivo estrogenic effects of two fluorotelomer alcohols, such as 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) and 1H,1H,2H,2H-perfluorodecan-1-ol (8:2 FTOH), in male medaka (Oryzias latipes). 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An in vitro yeast two-hybrid assay indicated a significant, dose-dependent interaction between medaka estrogen receptor α (ERα) and coactivator TIF2 upon treatment with 6:2 FTOH, 8:2 FTOH or 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluoro-1-decanol (NFDH). The relative ranks of tested chemicals on the estrogenic effects for medaka ERα descended in the order of estradiol-17β (100)≫6:2 FTOH (0.16)&gt;NFDH (0.016)&gt;8:2 FTOH (0.0044). In contrast, no interaction with the ERα was observed upon treatment with perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorododecanoic acid (PFDA) or perfluoroundecanoic acid (PFUnDA). Expression analysis of hepatic vitellogenin (VTG) protein showed estrogenic potentials with, 6:2 FTOH and 8:2 FTOH, indicative of the induction of VTG synthesis in the livers of male medaka. We also investigated mRNA expression levels of two ER subtypes (ERα and β) and two VTGs (VTG I and VTG II) in the livers of male medaka following exposure to FTOHs. Quantitative real-time polymerase chain reaction analyses revealed that hepatic ERα, VTG I, and VTG II mRNA responded rapidly to FTOHs such as 6:2 FTOH and 8:2 FTOH after 8-h exposure, whereas no effects of these compounds on ERβ mRNA transcription were observed. These results from both in vitro and in vivo assays strongly suggest that certain FTOHs, such as 6:2 FTOH and 8:2 FTOH, induce hepatic VTG through activation of ERα in male medaka.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18334264</pmid><doi>10.1016/j.chemosphere.2008.01.065</doi><tpages>7</tpages></addata></record>
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source ScienceDirect Freedom Collection 2022-2024
subjects Alcohols - toxicity
Animal and plant ecology
Animal, plant and microbial ecology
Animals
Applied ecology
Biological and medical sciences
Ecotoxicology, biological effects of pollution
Estrogen Receptor alpha
Estrogen Receptor beta - genetics
Estrogen receptor α
Estrogens, Non-Steroidal - toxicity
Fluorocarbons - toxicity
Fluorotelomer alcohols
Fresh water ecosystems
Freshwater
Fundamental and applied biological sciences. Psychology
General aspects
Liver - drug effects
Liver - metabolism
Male
Oryzias - metabolism
Oryzias latipes
Receptors, Estrogen - genetics
RNA, Messenger - metabolism
Saccharomyces cerevisiae - genetics
Synecology
Vitellogenin
Vitellogenins - genetics
Water Pollutants, Chemical - toxicity
title Fluorotelomer alcohols induce hepatic vitellogenin through activation of the estrogen receptor in male medaka (Oryzias latipes)
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