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Association of Serum TSH With Handgrip Strength in Community-Dwelling Euthyroid Elderly

Despite apparent muscle weakness in overt or even subclinical hyperthyroidism, the effects of thyroid function in the reference range on muscle strength are unknown. To investigate the association of serum TSH and free T4 with handgrip strength (HGS) in euthyroid elderly. A nationally representative...

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Published in:The journal of clinical endocrinology and metabolism 2018-11, Vol.103 (11), p.3986-3992
Main Authors: Kim, Beom-Jun, Lee, Seung Hun, Isales, Carlos M, Hamrick, Mark W, Kwak, Mi Kyung, Koh, Jung-Min
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cited_by cdi_FETCH-LOGICAL-c4025-bc282bcf3b2c1ff160318869b198194a783babad40eff7c33c7c8492ff22b41b3
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creator Kim, Beom-Jun
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description Despite apparent muscle weakness in overt or even subclinical hyperthyroidism, the effects of thyroid function in the reference range on muscle strength are unknown. To investigate the association of serum TSH and free T4 with handgrip strength (HGS) in euthyroid elderly. A nationally representative population-based, cross-sectional study from the Korea National Health and Nutrition Examination Surveys. A total of 650 men aged ≥50 years and 533 postmenopausal women. HGS was measured using a digital grip strength dynamometer, and low muscle strength was defined based on the Korean specific cutoff point of HGS (28.9 and 16.8 kg in men and women, respectively). After adjustment for confounders, lower serum TSH but not free T4 was associated with lower HGS in men (P = 0.032). Compared with men with high-normal TSH, those with low-normal TSH consistently showed 5.0% lower HGS (P = 0.027), with a linear decrease in HGS across decreasing serum TSH quartiles (P for trend = 0.018). Men with low muscle strength had 22.0% lower serum TSH than those without (P = 0.015), and the odds for the risk of low muscle strength was 3.76 times higher among men with low-normal TSH than it was among those with high-normal TSH (P = 0.021). However, these associations were not observed in postmenopausal women. These results suggest that serum TSH level at the lower end of reference range may be associated with low muscle strength, especially in older men.
doi_str_mv 10.1210/jc.2018-01095
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Men with low muscle strength had 22.0% lower serum TSH than those without (P = 0.015), and the odds for the risk of low muscle strength was 3.76 times higher among men with low-normal TSH than it was among those with high-normal TSH (P = 0.021). However, these associations were not observed in postmenopausal women. 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source Oxford Journals Online
subjects Adult
Age Factors
Aged
Cross-Sectional Studies
Female
Geriatrics
Hand Strength - physiology
Humans
Hyperthyroidism
Independent Living - statistics & numerical data
Male
Middle Aged
Muscle strength
Muscle Strength Dynamometer
Nutrition Surveys - statistics & numerical data
Population studies
Post-menopause
Postmenopause - blood
Postmenopause - physiology
Reference Values
Republic of Korea
Sex Factors
Thyroid
Thyroid Function Tests - standards
Thyroid Gland - physiology
Thyroid-stimulating hormone
Thyrotropin - blood
Thyrotropin - physiology
Thyroxine
Thyroxine - blood
Thyroxine - physiology
Women
title Association of Serum TSH With Handgrip Strength in Community-Dwelling Euthyroid Elderly
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