Nucleophilic amination of methoxypyridines by a sodium hydride-iodide composite

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest. A new protocol for nucleophi...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (73), p.1324-1327
Main Authors: Pang, Jia Hao, Kaga, Atsushi, Chiba, Shunsuke
Format: Article
Language:English
Subjects:
Lithium
Sodium hydrides
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Summary:A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest. A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI).
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05979a