Multifunctional melanin-like nanoparticles for bone-targeted chemo-photothermal therapy of malignant bone tumors and osteolysis

• Published in: Biomaterials 2018-11, Vol.183, p.10-19
• Main Authors: Wang, Yitong, Huang, Quan, He, Xiao, Chen, Hui, Zou, Yuan, Li, Yiwen, Lin, Kaili, Cai, Xiaopan, Xiao, Jianru, Zhang, Qiang, Cheng, Yiyun
• Format: Article
• Language: English
• Subjects: Bone-targeted delivery; Chemo-photothermal therapy; Magnetic resonance imaging; Malignant bone tumor; Melanin-like nanoparticles
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2018.08.033

Malignant bone tumors associated with aggressive osteolysis are currently hard to be cured by the clinical strategies. Nevertheless, nanomedicine might provide a promising therapeutic opportunity. Here, we developed a multifunctional melanin-like nanoparticle for bone-targeted chemo-photothermal treatment of malignant bone tumors. The particle was originally fabricated from alendronate-conjugated polydopamine nanoparticle (PDA-ALN) that exhibited excellent photothermal effect and high affinity to hydroxyapatite. PDA/Fe-ALN significantly enhanced the magnetic resonance contrast of the bone tumors in vivo, suggesting that more PDA-ALN accumulated at the osteolytic bone lesions in the tumors compared with the non-targeting PDA. Chemodrug SN38 was efficiently loaded on PDA-ALN, and the drug release could be triggered by near-infrared irradiation and acidic stimulus. Finally, the combined chemo-photothermal therapy efficiently suppressed the growth of bone tumors and reduced the osteolytic damage of bones at a mild temperature around 43 °C. This study provides an efficient and robust nanotherapeutics for the treatment of malignant bone tumors.