Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption

Fixed drug eruption is a delayed type hypersensitivity reaction to a drug seen most frequently with antibiotics such as tetracyclines, sulfonamides, and NSAIDs such as naproxen and ibuprofen. Although H1-antihistamines rarely elicit cutaneous adverse effects, there have been a few reports in the lit...

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Bibliographic Details
Published in:Dermatology online journal 2018-08, Vol.24 (6)
Main Authors: Gupta, Aastha, Arora, Pooja, Malhotra, Purnima, Sardana, Kabir
Format: Article
Language:English
Subjects:
Adult
Drug Eruptions - drug therapy
Drug Eruptions - etiology
Drug Eruptions - pathology
Female
Glucocorticoids - administration & dosage
Histamine H1 Antagonists - adverse effects
Histamine H1 Antagonists - therapeutic use
Humans
Pheniramine - adverse effects
Pheniramine - therapeutic use
Respiratory Tract Infections - drug therapy
Skin Diseases, Vesiculobullous - chemically induced
Skin Diseases, Vesiculobullous - drug therapy
Skin Diseases, Vesiculobullous - pathology
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Summary:Fixed drug eruption is a delayed type hypersensitivity reaction to a drug seen most frequently with antibiotics such as tetracyclines, sulfonamides, and NSAIDs such as naproxen and ibuprofen. Although H1-antihistamines rarely elicit cutaneous adverse effects, there have been a few reports in the literature implicating them in causing fixed drug eruption, particularly the piperazine derivatives (hydroxyzine, cetirizine, levocetirizine), and loratadine. However, cutaneous drug reactions with the alkylamine derivatives like pheniramine maleate are extremely uncommon and fixed drug eruptions have not been reported with any of the alkylamine antihistamines to date. We herein report a case of multifocal bullous fixed drug eruption following ingestion of pheniramine maleate.
ISSN:1087-2108
1087-2108
DOI:10.5070/D3246040693