Differential effects of restrictive and malabsorptive bariatric surgery procedures on the serum lipidome in obese subjects

• Published in: Journal of clinical lipidology 2018-11, Vol.12 (6), p.1502-1512
• Main Authors: Ramos-Molina, Bruno, Castellano-Castillo, Daniel, Alcaide-Torres, Juan, Pastor, Óscar, de Luna Díaz, Resi, Salas-Salvadó, Jordi, López-Moreno, Javier, Fernández-García, José C., Macías-González, Manuel, Cardona, Fernando, Tinahones, Francisco J.
• Format: Article
• Language: English
• Subjects: Bariatric surgery; Lipidomics; Metabolomics; Obesity; Phospholipids; Sphingolipids
• ISSN: 1933-2874; 1876-4789
• DOI: 10.1016/j.jacl.2018.07.006

Bariatric surgery (BS) is the most effective treatment for severe obesity. Our group and others have previously reported that the type of BS (restrictive vs malabsorptive) can lead to different effects on the lipid profile and glucose homeostasis in morbidly obese patients. Furthermore, BS exerts significant changes in lipid metabolism, which are not yet fully understood and that might be dependent of surgical technique. The objective of this study was to evaluate the differential changes in the serum lipidomic profile of morbidly obese subjects who underwent two different BS techniques: sleeve gastrectomy (SG) (restrictive) and biliopancreatic diversion (BPD) (malabsorptive). This study included 37 morbidly obese patients (body mass index ≥ 40 kg/m2) who underwent either SG (n = 25) or BPD (n = 12). Serum lipid extracts were assessed at baseline and 6 months after BS and were analyzed in a ultra-high performance liquid chromatography time-of-flight mass spectrometry–based platform. SG not only restores the circulating levels of fatty acids and glycerolipids to similar levels to those observed in nonobese subjects but also results in a consistent increase of phospholipid and sphingolipid species, ranging from antioxidant plasmalogens to lipotoxic ceramides. BPD, however, leads to an overall reduction in circulating fatty acids, glycerolipids, phospholipids and sphingolipids, and a substantial increase of bile acids. Our lipidomic analysis suggests that the differential metabolic effects typically observed after restrictive vs malabsorptive BS procedures could be explained, at least partially, to BS-specific lipid changes and provides novel aspects of lipid remodeling in obesity during weight loss. •Lipidomic analysis reveals bariatric surgery-specific changes in the serum lipidome.•Sleeve gastrectomy reduces glycerolipids and free fatty acids but increases phospholipids and sphingolipids.•Changes in phospholipid metabolism after sleeve gastrectomy negatively correlate with weight loss.•Biliopancreatic diversion leads to an overall reduction in serum lipidome but an increase in bile acids.•Changes in sphingolipids after biliopancreatic diversion are correlated with cholesterol lipoproteins.