Naamidines H and I, Cytotoxic Imidazole Alkaloids from the Indonesian Marine Sponge Leucetta chagosensis

Two new imidazole alkaloids, naamidines H (1) and I (2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds (1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 µg/mL, respectively.

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-10, Vol.70 (10), p.1658-1660
Main Authors: Tsukamoto, Sachiko, Kawabata, Tetsuro, Kato, Hikaru, Ohta, Tomihisa, Rotinsulu, Henki, Mangindaan, Remy E. P, van Soest, Rob W. M, Ukai, Kazuyo, Kobayashi, Hisayoshi, Namikoshi, Michio
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
General pharmacology
HeLa Cells
Humans
Imidazoles - chemistry
Imidazoles - isolation & purification
Imidazoles - pharmacology
Indonesia
Inhibitory Concentration 50
Leucetta chagosensis
Marine
Marine Biology
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
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Description
Summary:Two new imidazole alkaloids, naamidines H (1) and I (2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds (1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 µg/mL, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np070246i