Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats

Traditional oral report indicates that Tectona grandis is used in the treatment of anaemia in Togo. For this purpose, the extract of T. grandis leaves is evaluated on anaemia model of rat induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Oral administration of T. grandi...

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Bibliographic Details
Published in:Fitoterapia 2008-07, Vol.79 (5), p.332-336
Main Authors: Diallo, Aboudoulatif, Gbeassor, Messanvi, Vovor, Ahoefa, Eklu-Gadegbeku, Kwashie, Aklikokou, Kodjo, Agbonon, Amegnona, Abena, Ange A., de Souza, Comla, Akpagana, Koffi
Format: Article
Language:English
Subjects:
Anaemia
Anemia - chemically induced
Anemia - drug therapy
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Female
General pharmacology
Hemoglobins - metabolism
Lamiaceae - chemistry
Male
Medical sciences
Osmotic resistance
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenylhydrazines - toxicity
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rats
Rats, Wistar
Tectona grandis
Time Factors
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Summary:Traditional oral report indicates that Tectona grandis is used in the treatment of anaemia in Togo. For this purpose, the extract of T. grandis leaves is evaluated on anaemia model of rat induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Oral administration of T. grandis extract at 1 g/kg/day and 2 g/kg/day, to the rats previously treated with phenylhydrazine, increased the concentration of haemoglobin, red blood cells number, haematocrit and reticulocytes rate. Moreover, the extract of T. grandis enhanced the osmotic resistance of the red blood cells that confirm the important presence of young red blood cells. These results support partially the traditional use of T. grandis in the treatment of anaemia.
ISSN:0367-326X
DOI:10.1016/j.fitote.2008.02.005