Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague–Dawley rats

3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats...

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Bibliographic Details
Published in:Food and chemical toxicology 2008-09, Vol.46 (9), p.3172-3177
Main Authors: Cho, Wan-Seob, Han, Beom Seok, Nam, Ki Taek, Park, Kidae, Choi, Mina, Kim, Seung Hee, Jeong, Jayoung, Jang, Dong Deuk
Format: Article
Language:English
Subjects:
3-Monochloropropane-1,2-diol
alpha-Chlorohydrin
Animals
Biological and medical sciences
Body Weight - drug effects
Carcinogenesis, carcinogens and anticarcinogens
Carcinogenicity
Carcinogenicity Tests
Carcinogens
Chemical agents
Female
Glycerol - analogs & derivatives
Glycerol - toxicity
Kidneys
Leydig cell tumor
Male
Medical sciences
Neoplasms - chemically induced
Neoplasms - pathology
Nephrology. Urinary tract diseases
Rats
Rats, Sprague-Dawley
Renal tubule carcinoma
SD rats
Survival Analysis
Tumors
Tumors of the urinary system
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Summary:3-Monochloropropane-1,2-diol (α-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400 ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400 ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400 ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400 ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2008.07.003