Electronystagmographic Analysis of Optokinetic Nystagmus for the Evaluation of Ocular Symptoms in Myasthenia Gravis

Ocular symptoms of 17 myasthenia gravis (MG) patients were examined by electronystagmographic registration of optokinetic nystagmus. The aim of this study was to replace the subjective methods used previously with a more reliable quantitative technique and thus assess ophthalmoplegy and diplopia, im...

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Bibliographic Details
Published in:Acta oto-laryngologica 1999-01, Vol.119 (6), p.629-632
Main Authors: TOTH, L, TOTH, A, DIOSZEGHY, P, REPASSY, G
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cholinesterase Inhibitors
Diseases of striated muscles. Neuromuscular diseases
Electrodiagnosis. Electric activity recording
Electronystagmography
Electronystagmography - instrumentation
Electronystagmography - methods
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Middle Aged
Muscle Weakness - diagnosis
Muscle Weakness - etiology
Muscle Weakness - physiopathology
Myasthenia Gravis - complications
Myasthenia Gravis - diagnosis
Myasthenia Gravis - physiopathology
Neurology
Nystagmus, Optokinetic - drug effects
Oculomotor Muscles - drug effects
Oculomotor Muscles - physiopathology
Pyridostigmine Bromide
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Summary:Ocular symptoms of 17 myasthenia gravis (MG) patients were examined by electronystagmographic registration of optokinetic nystagmus. The aim of this study was to replace the subjective methods used previously with a more reliable quantitative technique and thus assess ophthalmoplegy and diplopia, important initial symptoms in MG. Slow phase angular speed values of foveolar type optokinetic nystagmus in the horizontal plane at 10, 20 and 30°/s target speed were determined. Measurements were performed before and after administration of Mestinon, a reversible cholinesterase inhibitor. Twelve healthy volunteers were examined as controls under standard conditions. Results showed significant differences between MG patients and control group. Slow-phase angular speed was significantly larger after Mestinon administration (p
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489950180540