Cerebellopontine Angle Cisternal Infusion of NGF, BDNF and NT-3: Effects on Cochlear Neurons Disconnected from Central Target, Cochlear Nucleus: An in vivo quantitative study

Cochlear neurons need their synaptic contacts with both their peripheral (organ of Corti) and central (cochlear nucleus) targets for survival. We examined the in vivo effectiveness of the neurotrophins (NGF, BDNF and NT-3) on cochlear neuronal survival using our in vivo model, in which the central c...

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Bibliographic Details
Published in:Acta oto-laryngologica 2000, Vol.120 (4), p.473-479
Main Author: Sekiya, Tetsuji
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain-Derived Neurotrophic Factor - administration & dosage
Brain-Derived Neurotrophic Factor - pharmacology
Brain-Derived Neurotrophic Factor - physiology
Cell Survival
Cerebellopontine Angle
Cochlear Nerve - cytology
Cochlear Nerve - injuries
Cochlear Nerve - pathology
Cochlear Nucleus - physiology
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Infusion Pumps, Implantable
Male
Medical sciences
Miscellaneous
Nerve Degeneration - pathology
Nerve Growth Factor - administration & dosage
Nerve Growth Factor - pharmacology
Nerve Growth Factor - physiology
Neural Pathways
Neuropharmacology
Neurotrophin 3 - administration & dosage
Neurotrophin 3 - pharmacology
Neurotrophin 3 - physiology
Non tumoral diseases
Otorhinolaryngology. Stomatology
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
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Summary:Cochlear neurons need their synaptic contacts with both their peripheral (organ of Corti) and central (cochlear nucleus) targets for survival. We examined the in vivo effectiveness of the neurotrophins (NGF, BDNF and NT-3) on cochlear neuronal survival using our in vivo model, in which the central connection alone was selectively and quantitatively interrupted. The particular neurotrophins evaluated in the present study did not appear to have cochlear nerve rescue potential. However, the experimental model reported here can serve as a useful tool to investigate cochlear neuronal degeneration from the central side, which may lead to identification of effective mediators in the future.
ISSN:0001-6489
1651-2251
DOI:10.1080/000164800750045956