Comparative investigations of the influence of H sub(1)-antihistamines on the generation of reactive oxygen species by phagocytes

In addition to their antihistamine effects, H sub(1)-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drags, such as antiinflammatory effects, antiplatelet activity, supression of respiratory burst of professional phagocytes. In our previ...

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Bibliographic Details
Published in:Inflammation research 2008-01, Vol.57, p.S49-S50
Main Authors: Kralova, J, Nosal, R, Drabikova, K, Jancinova, V, Denev, P, Moravcova, A, Kubala, L, Ciz, M, Lojek, A
Format: Article
Language:English
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Summary:In addition to their antihistamine effects, H sub(1)-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drags, such as antiinflammatory effects, antiplatelet activity, supression of respiratory burst of professional phagocytes. In our previous study, we compared the effects of dithiaden and another selected H sub(1)-antihistamines on the production of reactive oxygen species (ROS) by stimulated phagocytes. Since the antioxidative effects of H sub(1)-antagonists are closely related to their anti-inflammatory activity, we have compared fourteen H sub(1)-antihistamines from different pharmacological generations on the respiratory burst of phagocytes and their antioxidative properties in cell-free systems in vitro.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-007-0624-0