Differential response to lithium between melancholic and non-melancholic unipolar depression

•The response to lithium could be greater in melancholic depressions.•Due to scarce data available and other limitations the results are preliminary.•Results are consistent with those reported with antidepressants. The purpose of this report was to review the evidence regarding the differential resp...

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Bibliographic Details
Published in:Psychiatry research 2018-11, Vol.269, p.183-184
Main Authors: Valerio, Marina P., Martino, Diego J.
Format: Article
Language:English
Subjects:
Adult
Depressive Disorder - diagnosis
Depressive Disorder - drug therapy
Depressive Disorder - psychology
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - psychology
Endogenous
Female
Humans
Lithium - therapeutic use
Major depressive disorder
Male
Middle Aged
Treatment
Treatment Outcome
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Summary:•The response to lithium could be greater in melancholic depressions.•Due to scarce data available and other limitations the results are preliminary.•Results are consistent with those reported with antidepressants. The purpose of this report was to review the evidence regarding the differential response to lithium treatment between patients with unipolar melancholic and non-melancholic depression. Three studies suggest that the prophylactic effect of lithium in maintenance treatment may be greater in melancholic depression. Another study reported that melancholic symptoms, such as weight loss and psychomotor disturbances, predict a better response to lithium augmentation. These preliminary data suggest that the response to lithium may be greater in melancholic than in non-melancholic depression, which could be the focus of further research.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2018.08.077