A B7‐CD28 family based signature demonstrates significantly different prognoses and tumor immune landscapes in lung adenocarcinoma

B7 family ligands and CD28 family receptors have complicated interaction for modulating immune functions. They play a central role in response to immunotherapy and outcome of patients with lung adenocarcinoma (LUAD). Thus, we analyzed B7‐CD28 family gene expression profiles in LUAD and generated a s...

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Bibliographic Details
Published in:International journal of cancer 2018-11, Vol.143 (10), p.2592-2601
Main Authors: Zheng, Shanbo, Luo, Xiaoyang, Dong, Chuanpeng, Zheng, Difan, Xie, Juntao, Zhuge, Lingdun, Sun, Yihua, Chen, Haiquan
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer
CD28
CD28 antigen
Epidermal growth factor receptors
Gene expression
Genomes
Immunotherapy
Leukocytes
lung adenocarcinoma
Lung cancer
Lungs
Medical prognosis
Medical research
PD-L1 protein
Prognosis
prognostic signature
TCGA
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Summary:B7 family ligands and CD28 family receptors have complicated interaction for modulating immune functions. They play a central role in response to immunotherapy and outcome of patients with lung adenocarcinoma (LUAD). Thus, we analyzed B7‐CD28 family gene expression profiles in LUAD and generated a signature to predict prognosis and immune host status. B7‐CD28 family gene expression profiles and clinical data of LUAD from The Cancer Genome Atlas (TCGA) were analyzed. In the training cohort, prognostic association was assessed and then a prognostic signature was built with stepwise multivariable Cox analysis. The signature was validated by Kaplan–Meier and multivariable Cox analysis in several published gene expression datasets and a Fudan University cohort. Expression of immune cell populations and other immunotherapy predictors was further investigated. In TCGA LUAD cohort, eight B7‐CD28 family genes had prognostic association with p values
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31764