The investigation of the relationships of demodex density with inflammatory response and oxidative stress in rosacea

The relationships of demodex density with systemic oxidative stress, inflammatory response, and clinical severity in rosacea are not clear. This study aimed to (a) analyze the levels of systemic oxidative stress, antioxidant capacity, inflammatory parameters, and matrix metalloproteinases (MMPs) in...

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Bibliographic Details
Published in:Archives of Dermatological Research 2018-11, Vol.310 (9), p.759-767
Main Authors: Falay Gur, Tuğba, Erdemir, Aslı Vefa, Gurel, Mehmet Salih, Kocyigit, Abdurrahim, Guler, Eray Metin, Erdil, Duygu
Format: Article
Language:English
Subjects:
Adult
Animals
Antioxidants
Aryldialkylphosphatase - blood
Arylesterase
Case-Control Studies
Confocal microscopy
Cytokines - blood
Dermatology
Female
Gelatinase B
Humans
IL-1β
Inflammation
Inflammation - complications
Interstitial collagenase
Male
Matrix metalloproteinase
Medicine
Medicine & Public Health
Microscopy, Confocal
Middle Aged
Mites
Original Paper
Oxidative Stress
Paraoxonase
Patients
Peroxidase
Phenotypes
Rosacea
Rosacea - etiology
Rosacea - immunology
Rosacea - metabolism
Sebum - metabolism
Serum levels
Severity of Illness Index
Skin Aging
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:The relationships of demodex density with systemic oxidative stress, inflammatory response, and clinical severity in rosacea are not clear. This study aimed to (a) analyze the levels of systemic oxidative stress, antioxidant capacity, inflammatory parameters, and matrix metalloproteinases (MMPs) in systemic circulation in patients with rosacea, (b) identify the relationship between mite density and both oxidative stress and inflammation, and (c) investigate the role of photoaging and sebum secretion in etiopathogenesis. Forty patients with rosacea and 40 age-, sex-, and skin phenotype-matched healthy volunteers were included in the study. Clinical disease severity of the patients was determined. Sebum levels were measured in both the groups, and photoaging was evaluated. Reflectance confocal microscopy was used to calculate demodex density. Serum total antioxidant capacity (TAC), total oxidant capacity (TOC), myeloperoxidase (MPO), MMP-1, MMP-9, arylesterase (ARES), interleukin-1β (IL-1β), paraoxonase-1 (PON-1), and tumor necrosis factor-α (TNF-α) levels were also analyzed. The patients with rosacea had significantly higher serum TOC and lower TAC levels ( p  
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-018-1857-1