Lobe-wise assessment of lung volume and density distribution in lung transplant patients and value for early detection of bronchiolitis obliterans syndrome

•Changes of lung density differed significantly between patients with / without early BOS.•BOS patients had increased lung volume and decreased lung density.•Changes indicate increased inflation and were pronounced in the lower lung lobes. To evaluate quantitative computed tomography (CT) measuremen...

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Bibliographic Details
Published in:European journal of radiology 2018-09, Vol.106, p.137-144
Main Authors: Dettmer, S., Suhling, H., Klingenberg, I., Otten, O., Kaireit, T., Fuge, J., Kuhnigk, J.M., Gottlieb, J., Haverich, A., Welte, T., Wacker, F., Vogel-Claussen, J., Shin, H.O.
Format: Article
Language:English
Subjects:
Adult
Aged
Bronchiolitis Obliterans - diagnostic imaging
Bronchiolitis Obliterans - pathology
Bronchiolitis obliterans syndrome
Chronic lung allograft dysfunction
Early Diagnosis
Female
Humans
Lung - diagnostic imaging
Lung - pathology
Lung Transplantation
Male
Middle Aged
Organ Size
Postoperative Complications - diagnostic imaging
Postoperative Complications - pathology
Prospective Studies
Quantitative lung analysis
Tomography, X-Ray Computed - methods
Young Adult
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Summary:•Changes of lung density differed significantly between patients with / without early BOS.•BOS patients had increased lung volume and decreased lung density.•Changes indicate increased inflation and were pronounced in the lower lung lobes. To evaluate quantitative computed tomography (CT) measurements of the lung parenchyma in lung transplant (LTx) patients for early detection of the bronchiolitis obliterans syndrome (BOS). 359 CT scans of 122 lung transplant patients were evaluated. Measurements of lung volume and density were performed for the whole lung and separately for each lobe. For longitudinal analysis the difference between the baseline at 6 months after LTx and follow-up examinations was calculated. Patients with and without BOS (matched 1:2) were compared at two different time points, the last examination before the BOS onset and the first examination within one year after BOS onset. 30 patients developed BOS during the follow-up period. Longitudinal changes in the lung volume and lung density measured on CT differed significantly between those patients with and without early BOS, in particular the difference of the inspiratory and expiratory lung volume (p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2018.07.016